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| Status |
Public on Sep 30, 2012 |
| Title |
Methotrexate activates aspects of inflammation in EA.hy 926 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Methotrexate (MTX) is an anti-folate drug used to treat inflammatory diseases such as rheumatoid arthritis. The changes induced by MTX were profiled within EA.hy 926 cells grown in normal (Hi) and low (Lo) folate. Several inflammatory genes were up regulated and several mitosis related genes were down regulated.
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| Overall design |
Hi and Lo cells were grown to confluence and maintained in fresh medium for 24 hours prior to treatment with 0.5uM MTX for 48 hours.
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| Contributor(s) |
Whitehead AS, Summers CM, Hammons AL, Jochems J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 08, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Alexander Steven Whitehead |
| E-mail(s) |
aswhiteh@upenn.edu
|
| Organization name |
University of Pennsylvania
|
| Department |
Pharmacology
|
| Lab |
Whitehead
|
| Street address |
421 Curie Blvd, 8th floor BRB
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA147539 |
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