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| Status |
Public on Apr 10, 2012 |
| Title |
Exacerbated T cell lymphoma in NOD.Stat5bTg mice is caused by selective activation of Stat5b in CD8+ thymocytes and can be prevented by inhibition of the Stat5b signaling pathway with chemoprevention agents |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
This study demonstrated that genetic background is critical to the STAT5B-mediated lymphomagenesis probably through regulation of STAT5B activation, which results in the alteration of many tumorigenic genes. Chemopreventive compounds that can reduce STAT5B phosphorylation and/or the STAT5B signaling pathway can efficiently block lymphomagenesis, demonstrating that the NOD.Stat5bTg mouse is an excellent model for testing novel chemopreventive strategies.
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| Overall design |
To elucidate the molecular mechanism underlying the activation of Stat5b upon lymphoma onset, we profiled gene expression in thymocytes of NOD.Stat5b mice, Gene expression was analyzed with the Illumina's MouseRef-8 v2.0 Expression beadchips
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| Contributor(s) |
Chen B, Yi B, Mao R, Liu H, Wang J, Guo B, Peiper S, Leonard WJ, She J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 18, 2011 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Jin-Xiong She |
| E-mail(s) |
jshe@gru.edu
|
| Phone |
706-721-3410
|
| Fax |
706-721-3688
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| URL |
http://www.cbgm.mcg.edu/
|
| Organization name |
Medical College of Georgia
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| Department |
Center for Biotechnology and Genomic Medicine
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| Street address |
1120 15th Street, CA4124
|
| City |
Augusta |
| State/province |
GA |
| ZIP/Postal code |
30912-2400 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA145519 |
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