|
| Status |
Public on Dec 01, 2012 |
| Title |
Expression profiling of human peripheral blood before and after omega 3 dietary supplement. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Patients with early stage CLL were recruited into the study and administered a course of omega 3 dietary supplements. Expression profiling of each patient was performed at baseline (before administering the supplement) and after consumption of supplements. Patients were divided into two groups according to the level of NFkB activation at baseline, and then within each of the two groups significant changes in gene expression between baseline and the highest dose of supplements consumed were sought.
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| |
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| Overall design |
Patients were divided into two groups based on initial NFkB levels being below (low expressers) or above (high expressers) the median NFkB Activity level (2.14x10^6 NFkB Luminescence units/µg protein). Within each group, paired two class SAM was performed using the maximum supplement dose for each patient versus the baseline.
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| Contributor(s) |
Hardman WE, Fahrmann JF, Ballester OM, Ballester G, Witte TR, Salazar AJ, Ion G, Primerano DA, Boskovic G, Denvir J |
| Citation(s) |
23193970 |
| Submission date |
Jun 01, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
James Denvir |
| E-mail(s) |
denvir@marshall.edu
|
| Organization name |
Marshall University School of Medicine
|
| Department |
Biochemistry and Microbiology
|
| Lab |
Genomics and Bioinformatics Core Facility
|
| Street address |
One John Marshall Drive
|
| City |
Huntington |
| State/province |
WV |
| ZIP/Postal code |
25755 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
|
| Samples (23)
|
| GSM735958 |
Blood-Patient # 1-Baseline-High_Initial_NFkB |
| GSM735959 |
Blood-Patient # 1-6caps-High_Initial_NFkB |
| GSM735960 |
Blood-Patient # 3-Baseline-High_Initial_NFkB |
| GSM735961 |
Blood-Patient # 3-6caps-High_Initial_NFkB |
| GSM735962 |
Blood-Patient # 8-Baseline-Low_Initial_NFkB |
| GSM735963 |
Blood-Patient # 8-6caps-Low_Initial_NFkB |
| GSM735964 |
Blood-Patient # 6-Baseline-Low_Initial_NFkB |
| GSM735965 |
Blood-Patient # 6-6caps-Low_Initial_NFkB |
| GSM735966 |
Blood-Patient # 5-Baseline-High_Initial_NFkB |
| GSM735967 |
Blood-Patient # 5-6caps-High_Initial_NFkB |
| GSM735968 |
Blood-Patient # 5-9caps-High_Initial_NFkB |
| GSM735969 |
Blood-Patient # 4-Baseline-High_Initial_NFkB |
| GSM735970 |
Blood-Patient # 4-3caps-High_Initial_NFkB |
| GSM735971 |
Blood-Patient # 4-6caps-High_Initial_NFkB |
| GSM735972 |
Blood-Patient # 3-9caps-High_Initial_NFkB |
| GSM735973 |
Blood-Patient # 1-9caps-High_Initial_NFkB |
| GSM735974 |
Blood-Patient # 7-Baseline-Low_Initial_NFkB |
| GSM735975 |
Blood-Patient # 7-6caps-Low_Initial_NFkB |
| GSM735976 |
Blood-Patient # 9-Baseline-Low_Initial_NFkB |
| GSM735977 |
Blood-Patient # 9-6caps-Low_Initial_NFkB |
| GSM735978 |
Blood-Patient # 2-Baseline-High_Initial_NFkB |
| GSM735979 |
Blood-Patient # 2-6caps-High_Initial_NFkB |
| GSM735980 |
Blood-Patient # 2-9caps-High_Initial_NFkB |
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| Relations |
| BioProject |
PRJNA141199 |
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