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| Status |
Public on Dec 29, 2011 |
| Title |
In vitro knockdown of LAMP3 leads to down-regulation of interferon-inducible genes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We identified LAMP3 as a key driver gene of anti-viral subnetwork genes in cervical cancer patients. Therefore we tested this prediction using an in vitro system. This is the first direct demonstration of LAMP3 regulatory role in interferon-dependent immune response.
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| Overall design |
We first pretreated HeLa cells with control siRNA or LAMP3 siRNA overnight and then added 1 ng/ml of interferon alpha to the cultures for 3 and 4 days
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| |
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| Contributor(s) |
Shulzhenko N, Morgun A |
| Citation(s) |
23651994 |
| Submission date |
May 02, 2011 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Natalia Shulzhenko |
| E-mail(s) |
anemorgun@hotmail.com, shulzhenkon@niaid.nih.gov
|
| Organization name |
NIAID, USA
|
| Department |
Laboratory of Cellular and Molecular Immunology
|
| Lab |
Ghost lab
|
| Street address |
9000 Rockville Pike
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA140461 |
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