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| Status |
Public on Apr 15, 2011 |
| Title |
Genes regulated by Nkx2-3 in human intestinal microvascular endothelial cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Nkx2-3 is associated with inflammatory bowel disease (IBD). Nkx2-3 is expressed in microvascular endothelial cells and the muscuularis mucosa of the gastrointestinal tract. Human intestinal microvascular cells (HIMEC) are actively involved in the pathogenesis of IBD and IBD-associated microvascular dysfunction. To understand the cellular function of Nkx2-3 and its potential role underlying IBD pathogenesis, we investigated the genes regulated by Nkx2-3 in HIMEC usin cDNA microarray.
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| Overall design |
2 HIMEC lines (21B and 432) are used in thi study. For each HIMEC lines, either si-Nkx2-3 or contro vector was transfected 2 times to get biological replicates.
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| Contributor(s) |
Yu W, Hegarty JP, West G, Chen X |
| Citation(s) |
21637825 |
| Submission date |
Apr 15, 2011 |
| Last update date |
Aug 13, 2018 |
| Contact name |
wei yu |
| E-mail(s) |
weiyu@hmc.psu.edu
|
| Organization name |
pennsylvania state university
|
| Street address |
500 university drive
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| City |
hershey |
| ZIP/Postal code |
17033 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA138855 |
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