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Series GSE2853 Query DataSets for GSE2853
Status Public on Aug 23, 2005
Title Ciprofibrate (PPAR-alpha agonist) in the monkey liver
Platform organism Homo sapiens
Sample organism Macaca fascicularis
Experiment type Expression profiling by array
Summary Liver gene expression was examined in male cynomolgus monkeys treated with ciprofibrate (PPAR-alpha agonist) for 4 days at 400 mg/kg/day and treated for 15 days at 0, 3, 30, 150 or 400 mg/kg/day. The untreated control group were given only the vehicle (0.5% hydroxypropyl methylcellulose). Two animals per group were used for the 4 day treatment and four animals per group were used for the 15 day treatment (except the 15 day control group, which had three animals). Selection of significantly changed probesets was done using Rosetta Resolver and the fold-change and p values as determined by Resolver are given below. Affymetrix CEL files and MAS5-processed data have been made availabe for convenience. Note that data processing reported in the Toxicological Sciences manuscript was done using Rosetta Resolver and the treated versus control group fold-change and p-value are appended to the Series entry. An article has been published in Toxicological Sciences regarding this dataset; the data interpretation was based on the Rosetta Resolver data.
Keywords: repeat
 
Overall design Groups consisted of (i) vehicle only for 4 days, (ii) 400 mg/kg/day ciprofibrate for 4 days, (iii) vehicle only for 15 days and (iv) 3, 30, 150, or 400 mg/kg/day ciprofibrate for 15 days.
 
Contributor(s) Cariello NF
Citation(s) 16081524
Submission date Jun 30, 2005
Last update date Dec 13, 2018
Contact name Neal F Cariello
E-mail(s) neal.cariello@gmail.com
Phone 919 971 5307
Organization name GlaxoSmithKline
Department Safety Assessment
Lab Investigative Toxicology and Pathology
Street address 5 Moore Drive, Bldg 9, Rom 2011
City Research Triangle Park
State/province NC
ZIP/Postal code 27713
Country USA
 
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (23)
GSM62852 vehicle control 4 days biological replicate 1
GSM62853 vehicle control 4 days biological replicate 2
GSM62854 ciprofibrate at 400 mg/kg/day for 4 days biological replicate 1
Relations
BioProject PRJNA92565

Fold Change header descriptions
AffymetrixID
4day 400mg Cipro Fold-Change
15day 3mg Cipro Fold-Change
15day 30mg Cipro Fold-Change
15day 150mg Cipro Fold-Change
15day 400mg Cipro Fold-Change
4day 400mg Cipro P-value
15day 3mg Cipro P-value
15day 30mg Cipro P-value
15day 150mg Cipro P-value
15day 400mg Cipro P-value

Data table
AffymetrixID 4day 400mg Cipro Fold-Change 15day 3mg Cipro Fold-Change 15day 30mg Cipro Fold-Change 15day 150mg Cipro Fold-Change 15day 400mg Cipro Fold-Change 4day 400mg Cipro P-value 15day 3mg Cipro P-value 15day 30mg Cipro P-value 15day 150mg Cipro P-value 15day 400mg Cipro P-value
100_g_at 1.08 -1.34 -1.18 -1.17 1.04 0.48 0.12 0.25 0.43 0.78
1000_at 1.33 -1.06 -1.96 -1.1 1.21 0.49 0.91 0.00634 0.78 0.42
1001_at 1.13 -1.04 -1.1 -1.3 -1.58 0.52 0.91 0.79 0.46 0.19
1002_f_at 2.8 -1.06 1.19 2.36 2.33 9.03E-14 0.79 0.3 8.95E-15 1.89E-13
1003_s_at 1.03 1.34 1.1 1.35 1.06 0.97 0.72 0.89 0.67 0.95
1004_at 1.13 1.17 1.32 -1.13 -1.22 0.72 0.88 0.83 0.91 0.87
1005_at -1.52 -2.17 -1.68 -1.87 -3.44 0.16 0.00234 0.00235 0.0000582 0.000062
1006_at -2.98 1.12 -1.03 2.07 1.09 0.09 0.78 0.97 0.33 0.92
1007_s_at 1.17 1.15 1.43 1.04 1.12 0.83 0.64 0.52 0.93 0.53
1008_f_at -1.01 1.01 1.15 1.09 1.11 0.95 0.98 0.44 0.62 0.55
1009_at 1.3 1.02 -1.04 1.11 1.36 0.01 0.82 0.53 0.24 0.0000011
101_at 1.01 -2.59 1.46 1.09 1.02 0.99 0.15 0.71 0.93 0.99
1010_at 1.55 1.25 1.59 1.96 2.71 0.67 0.58 0.68 0.39 0.1
1011_s_at 1.6 2.44 2.06 2.11 1.51 0.08 0.02 0.08 0.08 0.26
1012_at -2.32 1.5 -1.1 -1.28 -1.51 0.3 0.5 0.9 0.71 0.57
1013_at -1.37 -1.1 -1.34 -1.31 -1.91 0.68 0.85 0.59 0.49 0.19
1014_at 1.78 1.36 1.04 1.13 1.28 0.42 0.22 0.92 0.81 0.55
1015_s_at 1.07 1.17 1.9 1.28 -1.12 0.91 0.87 0.4 0.79 0.9
1016_s_at -1.18 1.43 1.28 1.47 -1.57 0.76 0.28 0.63 0.35 0.28
1017_at -1.42 -1.13 1.02 -1.71 -1.51 0.48 0.7 0.97 0.32 0.24

Total number of rows: 12558

Table truncated, full table size 749 Kbytes.




Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE2853_RAW.tar 64.1 Mb (http)(custom) TAR (of CEL)

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