GEO Accession viewer

NCBI > GEO > Accession Display

Not logged in | Login

GEO help: Mouse over screen elements for information.

Series GSE2685

Query DataSets for GSE2685

Status

Public on May 22, 2005

Title

Global gene expression analysis of gastric cancer by oligonucleotide microarrays

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

To gain molecular understanding of carcinogenesis, progression, and diversity of gastric cancer, 22 primary human advanced gastric cancer tissues and 8 noncancerous gastric tissues were analyzed by high-density oligonucleotide microarray in this study. Based on expression analysis of approximately 6800 genes, a two-way clustering algorithm successfully distinguished cancer tissues from noncancerous tissues. Subsequently, genes that were differentially expressed in cancer and noncancerous tissues were identified; 162 and 129 genes were highly expressed (P < 0.05) >2.5-fold in cancer tissues and noncancerous tissues, respectively. In cancer tissues, genes related to cell cycle, growth factor, cell motility, cell adhesion, and matrix remodeling were highly expressed. In noncancerous tissues, genes related to gastrointestinal-specific function and immune response were highly expressed. Furthermore, we identified several genes associated with lymph node metastasis including Oct-2 or histological types including Liver-Intestine Cadherin. These results provide not only a new molecular basis for understanding biological properties of gastric cancer, but also useful resources for future development of therapeutic targets and diagnostic markers for gastric cancer.
Keywords: other

Contributor(s)

Hippo Y, Taniguchi H, Tsutsumi S, Machida N, Chong J, Fukayama M, Kodama T, Aburatani H

Citation(s)

11782383

Submission date

May 19, 2005

Last update date

Jul 08, 2016

Contact name

Shogo Yamamoto

E-mail(s)

yamamoto@genome.rcast.u-tokyo.ac.jp