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| Status |
Public on Jun 01, 2011 |
| Title |
Peroxireduxin-4 is over-expressed in colon cancer and its down-regulation leads to apoptosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The objective of this study was to gain insights into the biological basis of colon cancer progression by characterizing gene expression differences between normal colon epithelium, corresponding colorectal primary tumors and metastases. We found a close similarity in gene expression patterns between primary tumors and metastases, indicating a correlation between gene expression and morphological characteristics. PRDX4 was identified as highly expressed both in primary colon tumors and metastases, and selected for further characterization. Our study revealed that Prdx4 (PrxIV, AOE372) shows functional similarities to other Prx family members by negatively effecting apoptosis induction in tumor cells. In addition, our studies link Prdx4 with Hif-1α, a key regulatory factor of angiogenesis. Targeting Prdx4 may be an attractive approach in cancer therapy, as its inhibition is expected to lead to induction of apoptosis and blockade of Hif-1α-mediated tumor angiogenesis.
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| Overall design |
mRNA expression profiling of normal colon epithelium (5), primary colon tumors (12 with 1 replicate) and either lymph node metastases (9 with 2 replicates) or liver metastases (2) and cell lines (4) from twelve colon cancer patients.
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| Contributor(s) |
Leydold SM, Seewald M, Stratowa C, Kaserer K, Sommergruber W, Kraut N, Schweifer N |
| Citation |
Sandra M. Leydold, Michael Seewald, Christian Stratowa, Klaus Kaserer, Wolfgang Sommergruber, Norbert Kraut and Norbert Schweifer. Cancer Growth and Metastasis 2011:4 7-23. doi: 10.4137/CGM.S6584
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| Submission date |
Jan 11, 2011 |
| Last update date |
Jul 08, 2016 |
| Contact name |
Norbert Schweifer |
| E-mail(s) |
nschweifer@gmx.at
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| Organization name |
Boehringer Ingelheim Austria
|
| Street address |
Dr. Boehringer Gasse 5-11
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| City |
Vienna |
| ZIP/Postal code |
1120 |
| Country |
Austria |
| |
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| Platforms (1) |
| GPL80 |
[Hu6800] Affymetrix Human Full Length HuGeneFL Array |
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| Samples (32)
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| Relations |
| BioProject |
PRJNA136241 |
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