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| Status |
Public on Jun 09, 2011 |
| Title |
Microarray analysis of CaSki cell line grown as spheroids and adherent conditions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Microarry based whole genome expression analysis was done for the more tumorigenic CaSki spheroids cultures and the less tumorigenic CaSki adherent cultures to identify signaling mechanisms that vary between the two populations. Subsequent to this, an independent array was done to characterize the differences in gene expression between the cancer stem cell-like Lin-CD66+ and the bulk Lin- CD66- cells isolated from primary human cervical carcinomas. The second array was custom-designed and had genes implicated in stemness, epithelial differentiation, signaling pathways implicated in stemness (Notch and Wnt) and cell cylce-regulation.
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| Overall design |
Microarray analysis of CaSki cell line grown as spheroids and adherent conditions
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| Contributor(s) |
Krishna S, Bajaj J, Vivien E |
| Citation(s) |
21646470 |
| Submission date |
Jan 04, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Sudhir Krishna |
| E-mail(s) |
skrishna@ncbs.res.in
|
| Organization name |
National Centre for Biological Sciences, TIFR
|
| Street address |
UAS-GKVK Campus, Bellary Road
|
| City |
Bangalore |
| State/province |
Karnataka |
| ZIP/Postal code |
560065 |
| Country |
India |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE26419 |
Notch signaling in CD66+ cells drives the progression of human cervical cancers |
|
| Relations |
| BioProject |
PRJNA142251 |
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