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| Status |
Public on Apr 30, 2024 |
| Title |
Transcriptomic profiles of human aortic endothelial cell (HAOEC) which exposed to M(con) or M(Hb) macrophage supernatant |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Cell phenotype switching is increasingly being recognized in atherosclerosis. Intraplaque hemorrhage (IPH) is thought to be a major contributor to plaque progression in part by stimulating the influx of CD163+ macrophages.
We explored the hypothesis that CD163 macrophages cause plaque progression through the induction of pro-apoptotic endothelial to mesenchymal transition (EndMT) within the fibrous cap.
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| Overall design |
Transcriptomic profiles of human aortic endothelial cell (HAOEC) which exposed to M(con) or M(Hb) macrophage supernatant for 6 hours were examined by ClariomTM S microarray.
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| Contributor(s) |
Sakamoto A, Mori M, Kawakami R, Finn AV |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 20, 2024 |
| Last update date |
Apr 30, 2024 |
| Contact name |
Atsushi Sakamoto |
| E-mail(s) |
asakamoto@cvpath.org
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| Organization name |
CVPath Institute
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| Street address |
19 Firstfield Road
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| City |
Gaithersburg |
| State/province |
MD |
| ZIP/Postal code |
20878 |
| Country |
USA |
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| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA1090145 |
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