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| Status |
Public on Jan 14, 2011 |
| Title |
Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet.
Characterising the change in RNA expression in sperm in response to different paternal diets.
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| Overall design |
Examination of the effect of different diets, control diet, low-protein diet and caloric-restriction diet, on the RNA expression in the sperm. 8 samples: 3 are control diets and 2 are low protein diets 1 caloric restriction diet, and 2 samples from Epidydimal tissue.
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| Contributor(s) |
Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ |
| Citation(s) |
21183072 |
| Submission date |
Dec 07, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
naomi habib |
| E-mail(s) |
naomih@cs.huji.ac.il
|
| Organization name |
Hebrew University
|
| Department |
Computer Scince
|
| Lab |
Friedman
|
| Street address |
Givat-Ram
|
| City |
Jerusalem |
| ZIP/Postal code |
91904 |
| Country |
Israel |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
|
| GSM635857 |
Sperm RNA in mice under Control diet A |
| GSM635858 |
Sperm RNA in mice under Control diet B |
| GSM635859 |
Sperm RNA in mice under low protein diet C |
| GSM635860 |
Sperm RNA in mice under low protein diet D |
| GSM635861 |
Epididymal RNA in mice under Control diet E |
| GSM635862 |
Epididyma RNA in mice under low protein diet F |
| GSM635863 |
Sperm RNA in mice under Control diet G |
| GSM635864 |
Sperm RNA in mice under Caloric restrictive diet H |
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| This SubSeries is part of SuperSeries: |
| GSE25899 |
Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals |
|
| Relations |
| BioProject |
PRJNA142461 |
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