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| Status |
Public on May 01, 2024 |
| Title |
Intestinal NSD2 aggravates hepatic steatosis during obesity through histone modifications [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The impairment of the intestinal barrier will lead to the accumulation of fat and harmful substances in the liver, inducing hepatic steatosis or steatohepatitis. Zhang et al. identified NSD2 in the intestine as a novel and essential regulator of hepatic steatosis. NSD2 directly regulates transcriptional activation of ERN1 through the modification of H3 dimethylated on lysine 36 (H3K4me36), thereby activating the ERN1-JNK axis to induce inflammatory response, intestinal barrier impairment, and hepatic steatosis. This functional mechanism of NSD2 provides a potential therapeutic target for this disease.
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| Overall design |
Intestinal-specific NSD2 disruption mice (NSD2∆IE) and controls (NSD2fl/fl) were treated with a 16-week HFCD diet, and colon tissues were collected for further study, with three replicate samples per group
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| Contributor(s) |
Zhang Y, Peng L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 31, 2024 |
| Last update date |
May 01, 2024 |
| Contact name |
YIJIA ZHANG |
| E-mail(s) |
a15215572002@icloud.com
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| Phone |
15215572002
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| Organization name |
Beijing University of Chemical Technology
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| Street address |
和平街道
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| City |
北京市 |
| ZIP/Postal code |
100029 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1071485 |
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