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| Status |
Public on May 03, 2024 |
| Title |
A Transcriptomic Dataset of Embryonic Murine Telencephalon |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Sex bias is known in the prevalence/pathology of neurodevelopmental disorders. Sex-dependent differences of the certain brain areas are known to emerge perinatally through the exposure to sex hormones, while gene expression patterns in the rodent embryonic brain does not seem to be completely the same between male and female. To investigate potential sex differences in gene expression and cortical organization during the embryonic period in mice, we conducted a comprehensive analysis of gene expression for the telencephalon at E11.5 (a peak of neural stem cell expansion) and E14.5 (a peak of neurogenesis) using bulk RNA-seq data. As a result, our data showed the existence of notable sex differences in gene expression patterns not obviously at E11.5, but clearly at E14.5 when neurogenesis has become its peak. These data can be useful for exploring potential contribution of genes exhibiting sex differences to the divergence in brain development. Additionally, our data underscore the significance of studying the embryonic period to gain a deeper understanding of sex differences in brain development.
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| Overall design |
To investigate potential sex differences in gene expression and cortical organization during the embryonic period in mice, we conducted a comprehensive analysis of gene expression for the telencephalon at E11.5 (a peak of neural stem cell expansion) and E14.5 (a peak of neurogenesis).
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| Contributor(s) |
Manabe S, Ochi S, Takako K, Ebrahimiazar S, Kimura R, Yoshizaki K, Osumi N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 10, 2024 |
| Last update date |
May 03, 2024 |
| Contact name |
Shohei Ochi |
| E-mail(s) |
Shohei.ochi.a5@tohoku.ac.jp
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| Phone |
+81-22-717-8203
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| Organization name |
Tohoku University Graduate School of Medicine
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| Department |
Developmental Neuroscience
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| Lab |
Osumi Laboratory
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| Street address |
2-1, Seiryo-machi, Aoba-ku
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| City |
Sendai |
| State/province |
Miyagi |
| ZIP/Postal code |
980-8575 |
| Country |
Japan |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA1063246 |
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