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| Status |
Public on Feb 01, 2011 |
| Title |
Genome wide gene expression profiles of Drosophila l(3)mbt larval brains and cultured tumors |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
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| Summary |
Mutants in the Drosophila gene lethal (3) malignant brain tumor cause malignant growth in the larval brain. This data shows the changes in gene expression profile associated to mutations in l(3)mbt, both in situ in third instar larval brains and in tumors cultured for 1 5 and 10 (T1, T5, T10) rounds of allograft culture
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| Overall design |
We performed genome-wide gene expression profiling of l(3)mbt[E2] and l(3)mbt[ts1] homozygous and transheterozygous larval brains raised at restrictive temperatures (29º C). We obtained three replicates for l(3)mbt[E2] at 17ªC (MBT_E2_17), l(3)mbt[ts1] at 17ºC (MBT_TS1_17), l(3)mbt[E2] at 29ºC (MBT_E2_29) and the transheterozygous at 29ºC (MBT_TS1_ME2), and six replicates l(3)mbt[ts1] at 29ºC (MBT_TS1_29). We also obtained three replicates for l(3)mbt[ts1] tumors at the first (T1), fifth (T5) and tenth (T10) round of allograft culture in adult flies, and six replicates for wild type w[1118] flies (WT).
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| Contributor(s) |
Janic A, Rossell D, Gonzalez C |
| Citation(s) |
21205669 |
| Submission date |
Oct 25, 2010 |
| Last update date |
Aug 28, 2018 |
| Contact name |
David Rossell |
| E-mail(s) |
david.rossell@irbbarcelona.org
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| Organization name |
IRB Barcelona
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| Street address |
Baldiri Reixac 10
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| City |
Barcelona |
| ZIP/Postal code |
08028 |
| Country |
Spain |
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| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
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| Samples (33)
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| Relations |
| BioProject |
PRJNA132109 |
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