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| Status |
Public on Oct 23, 2010 |
| Title |
Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Acupuncture at acupoints GB34 and LR3 has been reported to inhibit nigrostriatal degeneration in parkinsonism models, yet the genes related to this preventive effect of acupuncture on the nigrostriatal dopaminergic system remain elusive.
We investigated gene expression profile changes in the striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3
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| Overall design |
C57BL/6 mice were divided into four experimental groups; ① C: Control, ② M: MPTP-treatment only, ③ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, ④ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' striatal regions of each experimental group (4 experimental group × 2 samples of each experimental group = total 8 samples).
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| Contributor(s) |
Choi Y, Yeo S, Hong Y, Lim S |
| Citation(s) |
21107677 |
| Submission date |
Oct 20, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Sabina Lim |
| E-mail(s) |
lims@khu.ac.kr
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| Phone |
82-2-961-0324
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| Organization name |
East-West Medical Research Institute, Kyung Hee University
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| Lab |
Research Group of Pain and Neuroscience
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| Street address |
#1 Hoegi-dong Dongdaemoon-gu
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| City |
Seoul |
| ZIP/Postal code |
130-701 |
| Country |
South Korea |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| GSM611084 |
MPTP-treated mouse 2 striatal regions |
| GSM611085 |
MPTP and acupoints acupuncture-treated mouse 1 striatal regions |
| GSM611086 |
MPTP and acupoints acupuncture-treated mouse 2 striatal regions |
| GSM611087 |
MPTP and nonacupoints acupuncture-treated mouse 1 striatal regions |
| GSM611088 |
MPTP and nonacupoints acupuncture-treated mouse 2 striatal regions |
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| This SubSeries is part of SuperSeries: |
| GSE24838 |
Gene expression data from brain striatal and spinal cord regions of MPTP-intoxicated mouse following acupuncture |
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| Relations |
| BioProject |
PRJNA133423 |
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