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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 23, 2010 |
| Title |
Intestinal ablation of CKIalpha highlights invasiveness control |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Wnt signaling, which drives the rapid self-renewal of the gut epithelium is causally associated with intestinal neoplasia. Here we show that CKIalpha is a activation depends on p53 and p21Waf1/Cip1: CKIα ablation provokes activation of p53 and p21, which assume a pivotal role in suppressing invasive cancer. Dual loss of CKIalpha and either p53 or p21 results in rapid, rampant malignant signature denoted p53supinv (p53-suppressed invasiveness) that is conditionally induction of invasiveness. Like invasiveness control, the transcriptional suppression of p53supinv genes is largely mediated by p21, independently of cell cycle control, representing a novel tumor suppressor function of wild-type p53.
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| Overall design |
13 arrays of mice entrocytes herto or homozygot for gut specific KO of CKI alpha. Crossed with p53 or p21 KO mice.
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| Contributor(s) |
Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y |
| Citation missing |
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| Submission date |
Oct 18, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Gady Cojocaru |
| E-mail(s) |
gadyk@compugen.co.il
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| Organization name |
hadassah medical center
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| Department |
Pathology
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| Lab |
Eli Pikarsky
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| Street address |
Kiryat Hadassah
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| City |
Jerusalem |
| ZIP/Postal code |
91120 |
| Country |
Israel |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA132161 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24760_RAW.tar |
54.9 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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