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Series GSE2393

Query DataSets for GSE2393

Status

Public on Mar 10, 2005

Title

Expression patterns throughout disease progression and impact on neuroAIDS.

Platform organism

Homo sapiens

Sample organism

Macaca mulatta

Experiment type

Expression profiling by array

Summary

The virus/host interactions during the acute phase of human immunodeficiency virus (HIV) infection help determine the course of disease. During this time period, virus enters the brain. Here, we report clusters of genes whose transcripts are significantly upregulated in the frontal lobe of the brain during acute simian immunodeficiency virus (SIV) infection of rhesus monkeys. Many of these genes are involved in interferon (IFN) and/or interleukin (IL)-6 pathways. Although neither IFNa nor IFN? are elevated in the brain, IL6 is increased. Both IFNa and IL6 are elevated in plasma during this acute phase. The upregulation of STAT1, verified by immunohistochemical staining, can be due to both central nervous system (CNS) (SIV and IL6) and peripheral (IFNa and IL6) causes, and can itself drive the expression of many of these genes. Examination of the levels of expression of the upregulated genes in the post-acute and long-term phases of infection, as well as in SIV encephalitis, reveals increased expression throughout SIV infection, which may serve to protect the brain, but can have untoward long-term consequences.
Keywords = HIV dementia
Keywords = Gene array
Keywords = Cytokine
Keywords = Simian immunodeficiency virus
Keywords: other

Web link

http://www.scripps.edu/researchservices/dna_array/

Contributor(s)

Head SR, Roberts E, Burudi EM, Flynn C, Madden LJ, Roinick KL, Watry DD, Zandonatti MA, Taffe MA, Fox HS, Henriksen SJ

Citation(s)

15579284

Submission date

Mar 09, 2005

Last update date

Dec 13, 2018

Contact name

Steven Head