|
| Status |
Public on Feb 22, 2012 |
| Title |
Whole genome expression data from human urinary bladder cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
At diagnosis approximately 75% of bladder urothelial carcinomas are non muscle invasive bladder cancers (Ta, T1 and Tis), 20% are muscle invasive bladder cancer (T2-T4) and 5% are already metastatic. Non muscle invasive bladder cancers are characterized by tumor recurrence in 60% to 85% of cases and, therefore, long-term followup is needed. The current standard methods to detect and monitor bladder cancer are cystoscopy and cytology. Cystoscopy is an invasive method and cytology is hampered by low sensitivity, especially for low grade tumors. So there is need to develop reliable and noninvasive methods to detect and predict bladder cancer biological behavior. So we have performed high density oligonucleotide microarray for discovery of new molecular markers to diagnose and predict the outcome of bladder cancer.
|
| |
|
| Overall design |
Under an ethical guideline of Chhatrapati Shahuji Maharaj Medical University, India histologically confirmed seven bladder cancer patients were recruited from Department of Urology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India. Total RNA was extracted from tumor biopsies and hybridized on affymetrix Human Gene ST 1.1 array to determine differentially expressed genes in urinary bladder cancer with muscle invasion in comparison of normal human urinary bladder.
|
| |
|
| Contributor(s) |
Singh PK, Rath SK, Bhatt MB |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 20, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Pankaj Kumar Singh |
| E-mail(s) |
pankajkgmu03@gmail.com
|
| Phone |
+91-522-2258877
|
| Fax |
+91-522-2258878
|
| Organization name |
Chhatrapati Shahuji Maharaj Medical University
|
| Department |
Radiotherapy
|
| Lab |
Radiotherapy
|
| Street address |
Chowk
|
| City |
Lucknow |
| State/province |
Uttar Pradesh |
| ZIP/Postal code |
226003 |
| Country |
India |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA130787 |
Less...
More...