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| Status |
Public on Oct 01, 2010 |
| Title |
Expression data of MMTV-PyMT mice mammary tumor with or without JAM-A |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Junction Adhesion Molecule-A (JAM-A) is present on leukocytes and platelets where it promotes cell adhesion and motility. We are interested in an interaction between JAM-A and tumor progression/metastases. To address this point, we mated JAM-A-/- mice and mouse mammary tumor model MMTV-PyMT mice which, which express polyoma middle T antigen under the control of mouse mammary tumor virus. MMTV-PyMT mice show 100% penetration of mammary tumor and highly metastases to lung. MMTV-PyMT mice without JAM-A show less primary tumor progression, therefore JAM-A enhance primary tumor progression. Then we are addressing the molecular mechanism of this phenomenon by in vivo. Furthermore, we would like to examine JAM-A deficient MMTV tumor signature.
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| Overall design |
Each 3 MMTV-PyMT JAm-A+/+ (JamA+) and 3 MMTV JAM-A-/- (JamA-) mammary tumor were resected at early stages of tumor development for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Murakami M |
| Citation(s) |
21695058 |
| Submission date |
Jun 24, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
gabriele bucci |
| E-mail(s) |
bucci.gabriele@hsr.it
|
| Phone |
+39026439140
|
| Organization name |
IRCCS Ospedale San Raffaele
|
| Department |
CTGB
|
| Street address |
via olgettina 58
|
| City |
Milano |
| State/province |
MI |
| ZIP/Postal code |
20100 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA128447 |
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