|
| Status |
Public on Jun 05, 2010 |
| Title |
Comparison of splenic and small intestine lamina propria dendritic cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Dendritic cells play a vital role in initiating robust immunity against pathogens as well as maintaining immunological tolerance to self antigens, food antigens and intestinal commensals. However, the intracellular signaling networks that program DCs to become tolerogenic are largely unknown. To address this, we analyzed gene expression profiles using microarray analysis of purified intestinal lamina propria DCs (CD11c+ CD11b+ DCs and CD11c+ CD11b- DCs) and compared it to splenic DCs (CD11c+ DC), from mice.
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
We sought to determine the unique genetic profile of small intestine lamina propria CD11c+ cells compared to splenic CD11c+ cells. We performed a meta-analysis using the expression profiles of Intestinal lamina propria CD11c+ CD11b+ DCs (GSM550122), Intestinal lamina propria CD11c+ CD11b- DCs (GSM550121) and Splenic CD11c+ DCs (GSM550126). This study combined and re-normalized the microarray data from GSE22127 and GSE22128 studies.
Refer to individual Series for additional details
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| Citation(s) |
20705860 |
| Submission date |
Jun 04, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Helder I. Nakaya |
| E-mail(s) |
hnakaya@usp.br
|
| Phone |
+551126481130
|
| Organization name |
Universidade de São Paulo
|
| Lab |
csbiology.com
|
| Street address |
AVENIDA PROFESSOR LINEU PRESTES, 580, Block 17
|
| City |
SÃO PAULO |
| State/province |
SÃO PAULO |
| ZIP/Postal code |
05508000 |
| Country |
Brazil |
| |
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| Platforms (2) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (3) |
| GSM550401 |
Intestinal lamina propria CD11c+ CD11b- DCs |
| GSM550402 |
Intestinal lamina propria CD11c+ CD11b+ DCs |
| GSM550403 |
Splenic CD11c+ DCs |
|
| This SuperSeries is composed of the following SubSeries: |
| GSE22127 |
Expression profiling of small intestine lamina propria dendritic cells |
| GSE22128 |
Expression profiling of splenic dendritic cells |
|
| Relations |
| BioProject |
PRJNA127573 |
