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Status |
Public on Feb 20, 2023 |
Title |
Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition [CRISPR genomic screen] |
Organism |
Homo sapiens |
Experiment type |
Other
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Summary |
CRISPR/Cas9 screens identified unexpected hits in human AML cell lines whose loss of function causes resistance to SHP2 inhibition
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Overall design |
CRISPR/Cas9 screens in two human AML cell lines (MOLM13 and MV4-11) to identify resistant hits to SHP2 inhibitor (SHP099)
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Contributor(s) |
Wei W, Neel BG |
Citation missing |
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Submission date |
Nov 21, 2022 |
Last update date |
Feb 20, 2023 |
Contact name |
Igor Dolgalev |
Organization name |
NYU Grossman School of Medicine
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Street address |
550 1st Ave
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City |
New York |
State/province |
New York |
ZIP/Postal code |
10016 |
Country |
USA |
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Platforms (3) |
GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
GPL30173 |
NextSeq 2000 (Homo sapiens) |
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Samples (12)
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This SubSeries is part of SuperSeries: |
GSE218491 |
Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 Inhibition |
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Relations |
BioProject |
PRJNA903930 |