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| Status |
Public on Feb 02, 2005 |
| Title |
Identification of genes that are dysregulated in the telencephalon of Dlx1/2 mutants. Rubenstein-2R01MH049428-11 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The Dlx homeodomain transcription factors are implicated in regulating the function of inhibitory neurons; therefore understanding their functions will provide insights into disorders such as epilepsy, mental retardation, autism and cerebral palsy.
Identify genes that are dysregulated in the telencephalon of Dlx1/2 mutants. I am sending separate samples of the Basal Ganglia (BG) and cortex (Ctx).
Comparing gene expression in the embryonic basal ganglia and cortex in wild type and dlx1/2 mutant mice will provide information regarding the types of genes that are downstream of Dlx1/2 function.
Perform gene array analyses in duplicate or triplicate; compare expression profile of total RNA from wild type and dlx1/2 telencephalons. I am sending separate samples of the Basal Ganglia (BG) and cortex. I want to perform gene expression comparison between: 1) wild type and dlx1/2 basal ganglia (BG) 2) wild typee and dlx1/2 cortex (ctx) Age of all mice has been indicated as 14 days to satisfy system requirements, however all mice are embryonic day 14.5.
Keywords: other
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| Contributor(s) |
Rubenstein JL |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 14, 2005 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Winnie Liang |
| E-mail(s) |
wliang@tgen.org
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| Organization name |
Translational Genomics
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| Street address |
445 N. Fifth Street
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| City |
Phoenix |
| State/province |
AZ |
| ZIP/Postal code |
85012 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (8)
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| GSM38974 |
blood, adrenal medulla: BG +/- replicate 2_e1_le1 |
| GSM38975 |
blood, adrenal medulla: BG +/- replicate 3_e1_le1 |
| GSM38976 |
blood, adrenal medulla: BG -/- replicate 2_e1_le1 |
| GSM38977 |
blood, adrenal medulla: BG -/- replicate 3_e1_le1 |
| GSM38978 |
blood, adrenal medulla: Ctx +/- replicate 2_e1_le1 |
| GSM38979 |
blood, adrenal medulla: Ctx +/- replicate 3_e1_le1 |
| GSM38980 |
blood, adrenal medulla: Ctx -/- replicate 2_e1_le1 |
| GSM38981 |
blood, adrenal medulla: Ctx -/- replicate 3_e1_le1 |
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| Relations |
| BioProject |
PRJNA91427 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE2161_RAW.tar |
46.1 Mb |
(http)(custom) |
TAR (of CEL) |
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