|
| Status |
Public on Dec 07, 2023 |
| Title |
Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Analysis of RISC bound short (s)RNAs in various cell lines and mouse models of Alzheimer's disease and in human AD patients reveals a contribution of 6mer seed toxicity to the neurotoxicity associated with AD
|
| |
|
| Overall design |
Ago protein associated short RNAs were pulled down using a GW182 peptide and subjected to smRNA Seq
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| |
|
| Contributor(s) |
Bartom E, Peter M |
| Citation(s) |
38238311 |
| Submission date |
Sep 11, 2022 |
| Last update date |
Jan 29, 2024 |
| Contact name |
Marcus Peter |
| E-mail(s) |
m-peter@northwestern.edu
|
| Organization name |
Northwestern University Feinberg School of Medicine
|
| Street address |
303 East Superior Street, Lurie 6-123
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60611 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (6)
|
| GSM6573179 |
Young.2M.mouse.cortexNhippo.rep1 (DISE-022) |
| GSM6573180 |
Young.2M.mouse.cortexNhippo.rep2 (DISE-022) |
| GSM6573181 |
Young.2M.mouse.cortexNhippo.rep3 (DISE-022) |
| GSM6573182 |
Old.18M.mouse.cortexNhippo.rep1 (DISE-022) |
| GSM6573183 |
Old.18M.mouse.cortexNhippo.rep2 (DISE-022) |
| GSM6573184 |
Old.18M.mouse.cortexNhippo.rep3 (DISE-022) |
|
| This SubSeries is part of SuperSeries: |
| GSE213138 |
Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging |
|
| Relations |
| BioProject |
PRJNA879228 |
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