SNP genotyping by SNP array Genome variation profiling by SNP array
Summary
Sex chromosomal abnormalities areare associated with multiple defects. In this study, we retrospectively analyzed the single nucleotide polymorphism (SNP) arrays of 186 early embryos with sex chromosomal abnormalities. using single nucleotide polymorphism (SNP) array. Among them, 52 cases of Turner syndrome, 21 cases of triple X syndrome, 35 cases of Klinefelter syndrome and 14 cases of XYY syndrome were detected. Moreover, 27 cases of mosaic sex chromosomal abnormalities were determined. Sex chromosomal deletions and duplications were found in 37 cases. Overall, our results presented a detailed manifestation of sex chromosomal abnormalities.
Overall design
From 2019 to 2022, more than 10,000 cases of SNP arrays were conducted in our center. In this study, we retrospectively analyzed the SNP arrays of 186 early embryos with sex chromosomal abnormalities. Chromosome Analysis Suite (ChAS) and online databases were used for analyzing the SNP arrays and prenatal diagnosis. ------------------------------------ Author state "43 CEL files from December 2016 to August 2019 were lost. CYCHP files of 186 early embryos were submitted."
Less...
More...