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| Status |
Public on Aug 11, 2023 |
| Title |
Hepatic transcriptome profiling in beef cattle to determine the effects of fescue toxicity |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The objective of our study was to assess the effect of fescue toxicosis on the overall transcriptomics profile of liver tissue on growing Angus × Simmental steers and heifers. The susceptibility was determined by the T-snip genetic tests for a total of 42 pregnant cows. At mid-gestation, these animals were randomly assigned to control group which received a based diet and fed endophyte free fescue seeds; a treatment group was fed endophyte-infected tall fescue seeds for 30 days. RNA-seq experiments were performed in liver biopsy samples, and a total of 828 differentially expressed genes were detected.
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| Overall design |
Profile of transcriptome-wide gene expression changes in liver samples from Angus × Simmental cattle supplemented with endophyte-infected tall fescue seeds (n=3; data available under GSE206468) compared to control samples (n=3 susceptible and n=3 tolerant).
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| Contributor(s) |
Wang X, Moisa S |
| Citation(s) |
37535643 |
| Submission date |
Jul 14, 2022 |
| Last update date |
Aug 11, 2023 |
| Contact name |
Xu Wang |
| E-mail(s) |
xzw0070@auburn.edu
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| Organization name |
Auburn University
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| Department |
Pathobiology, College of Veterinary Medicine
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| Street address |
273 CASIC Building, Auburn Research Park, 559 Devall Dr
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| City |
Auburn University |
| State/province |
AL |
| ZIP/Postal code |
36849 |
| Country |
USA |
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| Platforms (1) |
| GPL26012 |
Illumina NovaSeq 6000 (Bos taurus) |
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| Samples (9)
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| GSM6339495 |
9001G, liver, tolerant, control |
| GSM6339496 |
9008G, liver, tolerant, control |
| GSM6339497 |
9093G, liver, tolerant, control |
| GSM6339498 |
9036G, liver, treatment |
| GSM6339499 |
9056G, liver, treatment |
| GSM6339500 |
9120G, liver, treatment |
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| Relations |
| BioProject |
PRJNA858832 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208241_cattle_liver_seed_effect_raw_counts.txt.gz |
347.4 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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