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| Status |
Public on Jun 11, 2022 |
| Title |
Mechanisms of drugs-resistance in small cell lung cancer II |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Malignant transformation of SCLC often occurs simultaneously with the acquisition of chemotherapy resistance, suggesting that phenotypic malignant transformation is associated with adaptation to chemotherapy-induced stress. Recently, it has been reported that autophagy deficiency is involved in chemotherapy resistance in SCLC. To analyze gene expression changes associated with SCLC malignant transformation, we established ATG7 knockout and ATG7/SQSTM1 double knockout SCLC cell lines and performed RNA sequencing.
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| Overall design |
ATG7 Knockout and ATG7/SQSTM1 double knockout DMS273 cells were generated by CRISPRv2 vector. RNAs were isolated from each generated DMS273 cells and subjected RNA-sequencing analysis.
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| Contributor(s) |
Suina K, Yamasaki J, Okazaki S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 06, 2022 |
| Last update date |
Jun 11, 2022 |
| Contact name |
Shogo Okazaki |
| Organization name |
Nihon University
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| Department |
School of Dentistry
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| Lab |
Depertment of Microbiology and Immunology
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| Street address |
1-8-13 Kanda-Surugadai
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| City |
Chiyoda-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
101-8310 |
| Country |
Japan |
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| Platforms (1) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA846261 |
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