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| Status |
Public on Jun 06, 2022 |
| Title |
Modulation of behavioral and hippocampal transcriptomic responses in rat prolonged chronic unpredictable stress model by fluoxetine, eicosapentaenoic acid and lipopolysaccharide |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here, we examine behavioral and brain transcriptomic (RNA-seq) responses in rat prolonged chronic unpredictable stress (PCUS) model, and their modulation by 4-week treatment with fluoxetine, eicosapentaenoic acid (EPA), lipopolysaccharide (LPS) and their combinations.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for hippocampus of wistar male rats (n=3) subjected to 12 weeks of chronic unpredictable stress (CUS; 1) or rats also subjected to fluoxetine (2), lipopolysacharide (3), eicosapentaenoic acid (4), fluoxetine + eicosapentaenoic acid (5), and fluoxetine + lipopolysacharide (6) for last 4 weeks of CUS or experimentally naive rats (7).
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| Contributor(s) |
Demin KA, Kolesnikova TO, Galstyan DS, Krotova NA, Ilyin NP, Derzhavina KA, Seredinskaya M, Kositsyn YM, Sorokin DV, Nerush MO, Khaybaev AS, Pushkareva SA, Strekalova T, Masharsky A, Kalueff AV |
| Citation(s) |
36460699 |
| Submission date |
Jun 01, 2022 |
| Last update date |
Jan 03, 2023 |
| Contact name |
Konstantin Andreevich Demin |
| E-mail(s) |
deminkasci@gmail.com
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| Organization name |
Saint Petersburg State University
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| Street address |
University Embankment, 7/9
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| City |
St Petersburg |
| ZIP/Postal code |
199034 |
| Country |
Russia |
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| Platforms (1) |
| GPL22396 |
Illumina HiSeq 4000 (Rattus norvegicus) |
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| Samples (21)
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| GSM6210417 |
Hippocampus stress, eicosapentaenoic acid 1 |
| GSM6210418 |
Hippocampus stress, eicosapentaenoic acid 2 |
| GSM6210419 |
Hippocampus stress, eicosapentaenoic acid 3 |
| GSM6210420 |
Hippocampus stress, fluoxetine 1 |
| GSM6210421 |
Hippocampus stress, fluoxetine 2 |
| GSM6210422 |
Hippocampus stress, fluoxetine 3 |
| GSM6210423 |
Hippocampus stress, fluoxetine and eicosapentaenoic acid 1 |
| GSM6210424 |
Hippocampus stress, fluoxetine and eicosapentaenoic acid 2 |
| GSM6210425 |
Hippocampus stress, fluoxetine and eicosapentaenoic acid 3 |
| GSM6210426 |
Hippocampus stress, fluoxetine and lipopolysacharide 1 |
| GSM6210427 |
Hippocampus stress, fluoxetine and lipopolysacharide 2 |
| GSM6210428 |
Hippocampus stress, fluoxetine and lipopolysacharide 3 |
| GSM6210429 |
Hippocampus stress, lipopolysacharide 1 |
| GSM6210430 |
Hippocampus stress, lipopolysacharide 2 |
| GSM6210431 |
Hippocampus stress, lipopolysacharide 3 |
| GSM6210432 |
Hippocampus stress 1 |
| GSM6210433 |
Hippocampus stress 2 |
| GSM6210434 |
Hippocampus stress 3 |
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| Relations |
| BioProject |
PRJNA844390 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE205325_CUS_Rats_Counts.xlsx |
3.4 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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