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| Status |
Public on Mar 16, 2023 |
| Title |
Secretogranin II influences the assembly and function of MHC class I in melanoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Melanoma is the deadliest form of skin cancer showing rising incidence over the past years. New insights into the mechanisms of melanoma progression contributed to the development of novel treatment options, such as immunotherapies. However, acquiring resistance to treatment poses a big problem to therapy success. Therefore, understanding the mechanisms underlying resistance could improve therapy efficacy. By conducting transcriptional analysis between SCG2-overexpressing (OE) and control melanoma cells, we detected a downregulation of components of the antigen presenting machinery (APM), which is important for the assembly of the MHC class I complex.
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| Overall design |
Total RNA isolated from SCG2 overexpressing melanoma cell lines and its control cell lines
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| Contributor(s) |
Steinfass T, Utikal J |
| Citation(s) |
36906639 |
| Submission date |
May 17, 2022 |
| Last update date |
Mar 17, 2023 |
| Contact name |
Jochen Utikal |
| Organization name |
German Cancer Research Center
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| Department |
Clinical Cooperation Unit Dermato-Oncology
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| Lab |
Utikal Lab
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| Street address |
Im Neuenheimer Feld 280
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| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA838958 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE203179_C32_results.xlsx |
3.0 Mb |
(ftp)(http) |
XLSX |
| GSE203179_RAW.tar |
13.8 Mb |
(http)(custom) |
TAR (of CEL) |
| GSE203179_WM266_results.xlsx |
2.9 Mb |
(ftp)(http) |
XLSX |
| Processed data are available on Series record |
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