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| Status |
Public on Sep 01, 2010 |
| Title |
Expression data from tamoxifen treated and control injection treated Tg(αMHC-MerCreMer) and wild type mus musculus. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
α-myosin heavy chain promoter controlled MerCreMer expression enables conditional, cardiomyocyte specific and tamoxifen dependent gene inactivation of floxed genes. Administration of tamoxifen has been linked to development of acute and transient cardiomyopathy. The mechanism for this is unknown.
We used microarrays to sort out factors relevant for adverse effects following tamoxifen dependent gene inactivation, to develop a protocol with minimal adverse effects, and to identify the most proper control animals.
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| Overall design |
Mus musculus Tg(αMHC-MerCreMer) and wild type were sacrificed 4 days after 1 or 4 consecutive days of 40 mg/kg tamoxifen injected intraperitoneally, or after corresponding control injection treatment.
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| Contributor(s) |
Hougen K, Nygård S, Sjaastad I |
| Citation(s) |
20802136 |
| Submission date |
Dec 07, 2009 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Karina Hougen |
| Organization name |
University of Oslo
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| Street address |
Kirkeveien 166
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| City |
Oslo |
| ZIP/Postal code |
0407 |
| Country |
Norway |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (21)
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| GSM480425 |
Tg(αMHC-MerCreMer), left ventricle, 1 ctrl injection, rep1 |
| GSM480426 |
Tg(αMHC-MerCreMer), left ventricle, 1 ctrl injection, rep2 |
| GSM480427 |
Tg(αMHC-MerCreMer), left ventricle, 1 ctrl injection, rep3 |
| GSM480428 |
Tg(αMHC-MerCreMer), left ventricle, 1 TAM injection, rep1 |
| GSM480429 |
Tg(αMHC-MerCreMer), left ventricle, 1 TAM injection, rep2 |
| GSM480430 |
Tg(αMHC-MerCreMer), left ventricle, 1 TAM injection, rep3 |
| GSM480431 |
Tg(αMHC-MerCreMer), left ventricle, 4 ctrl injection, rep1 |
| GSM480432 |
Tg(αMHC-MerCreMer), left ventricle, 4 ctrl injection, rep2 |
| GSM480433 |
Tg(αMHC-MerCreMer), left ventricle, 4 ctrl injection, rep3 |
| GSM480434 |
Tg(αMHC-MerCreMer), left ventricle, 4 TAM injection, rep1 |
| GSM480435 |
Tg(αMHC-MerCreMer), left ventricle, 4 TAM injection, rep2 |
| GSM480436 |
Tg(αMHC-MerCreMer), left ventricle, 4 TAM injection, rep3 |
| GSM480437 |
Wild type, left ventricle, 4 ctrl injection, rep1 |
| GSM480438 |
Wild type, left ventricle, 4 ctrl injection, rep2 |
| GSM480439 |
Wild type, left ventricle, 4 ctrl injection, rep3 |
| GSM480440 |
Wild type, left ventricle, 4 ctrl injection, rep4 |
| GSM480441 |
Wild type, left ventricle, 4 ctrl injection, rep5 |
| GSM480442 |
Wild type, left ventricle, 4 ctrl injection, rep6 |
| GSM480443 |
Wild type, left ventricle, 4 TAM injection, rep1 |
| GSM480444 |
Wild type, left ventricle, 4 TAM injection, rep2 |
| GSM480445 |
Wild type, left ventricle, 4 TAM injection, rep3 |
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| Relations |
| BioProject |
PRJNA121721 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE19344_RAW.tar |
77.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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