|
| Status |
Public on Jul 07, 2010 |
| Title |
Expression data from TKI258 treated 4T1 cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on the proliferation and survival of these cells.
We used microarray to understand the contribution of FGFR signaling to the tumorigenic phenotype of the 4T1 cells.
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|
| Overall design |
4T1 cells were grown in tissue culture and treated with TKI258 or DMSO as vehicle control for 16 hours. The RNA were extracted from three individual dishes per condition and hybridized on Affimetrix microarrays.
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| |
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| Contributor(s) |
Dey JH, Oakeley EJ |
| Citation(s) |
20460524 |
| Submission date |
Nov 30, 2009 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Julien Herve Dey |
| Organization name |
FMI
|
| Department |
growth control
|
| Lab |
Hynes
|
| Street address |
Maulbeerstrasse
|
| City |
Basel |
| ZIP/Postal code |
4058 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (6)
|
| GSM476147 |
4T1 treated with DMSO, biological replicate 1 |
| GSM476148 |
4T1 treated with DMSO, biological replicate 2 |
| GSM476149 |
4T1 treated with DMSO, biological replicate 3 |
| GSM476150 |
4T1 treated with TKI258, biological replicate 1 |
| GSM476151 |
4T1 treated with TKI258, biological replicate 2 |
| GSM476152 |
4T1 treated with TKI258, biological replicate 3 |
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| This SubSeries is part of SuperSeries: |
| GSE19222 |
Expression data from TKI258 treated 4T1 cells and 4T1 tumors |
|
| Relations |
| BioProject |
PRJNA123677 |
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