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| Status |
Public on Apr 04, 2005 |
| Title |
Differential Gene Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database reports gene expression in cultured human pulmonary artery endothelial cells (HPAEC) exposed to plasma from: a) sickle acute chest syndrome (ACS) patients (samples ; b) SCD patients at steady-state and c) normal volunteers using microarrays (U133A-B GeneChip Affymetrix).
Keywords: other
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| Contributor(s) |
Klings ES, Safaya S, Adewoe AH, Odhiambo A, Frampton G, Lenburg M, Sebastiani P, Steinberg MH, Farber HW |
| Citation(s) |
15741505 |
| Submission date |
Oct 19, 2004 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Paola Sebastiani |
| E-mail(s) |
sebas@bu.edu
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| Phone |
617 538 5877
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| Organization name |
Boston University
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| Street address |
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02118 |
| Country |
USA |
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| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL97 |
[HG-U133B] Affymetrix Human Genome U133B Array |
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| Samples (65)
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| Relations |
| BioProject |
PRJNA90467 |
| Supplementary data files not provided |
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