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| Status |
Public on Feb 17, 2010 |
| Title |
Molecular Stratification of Clear Cell Renal Cell Carcinoma Reveals Distinct Subtypes and Survival Patterns |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Renal cell carcinoma (RCC) tumors express varying gene profiles, dependent on varying genetic events.
Here we analyzed a series of ccRCC tumors to show that two subtypes of ccRCC exist based on their molecular signature. These subtypes (ccA and ccB) are identifiable by a robust set of genes representing distinct biological pathways and are correlated with patient survival post-nephrectomy.
Keywords: Patient sample study
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| Overall design |
RNA from 48 clear cell RCC tumors specimens and 18 corresponding non-tumor samples was hybridized against a modified commercial reference RNA (Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747–752) for gene expression analysis.
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| Contributor(s) |
Brannon AR, Reddy A, Seiler M, Arreola A, Pruthi R, Wallen E, Liu H, Ganesan S, Bhanot G, Rathmell WK |
| Citation(s) |
20871783 |
|
Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns. Genes and Cancer. February 2010 1: 152-163.
|
| Submission date |
Jun 05, 2009 |
| Last update date |
Aug 19, 2019 |
| Contact name |
Kimryn Rathmell |
| E-mail(s) |
kimryn.rathmell@vanderbilt.edu
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| Organization name |
Vanderbilt
|
| Department |
Medicine
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| Lab |
Rathmell
|
| Street address |
2220 Pierce Ave
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37232 |
| Country |
USA |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (70)
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| Relations |
| BioProject |
PRJNA116017 |
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