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| Status |
Public on Dec 08, 2020 |
| Title |
Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [P3] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is a well-documented feature in Alzheimer’s disease (AD). Herein, we investigated neuro-inflammation that emerges during mid-life aging, chronological and endocrinological, in the female brain as an early initiating mechanism driving AD risk later in life. Analyses were conducted in a translational rodent model of mid-life chronological and endocrinological aging followed by validation in transcriptomic profiles from women versus age-matched men. In the translational model, the neuroinflammatory profile of mid-life aging in females was endocrine and chronological state specific, dynamic, anatomically distributed and persistent. Microarray dataset analyses of aging human hippocampus indicated a sex difference in neuroinflammatory profile in which women exhibited a profile comparable to the pattern discovered in our translational rodent model, whereas age-matched men exhibited a profile consistent with low neuro-immune activation. Translationally, these findings have implications for therapeutic interventions during mid-life to decrease late-onset AD risk.
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| Overall design |
6 animals/group. Female animals were aged from 6 months to 16 months with different menapausing status.
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| Contributor(s) |
Brinton R, Yuan S, Fei Y, Aarti M |
| Citation(s) |
33319170 |
| Submission date |
Nov 09, 2020 |
| Last update date |
Apr 20, 2022 |
| Contact name |
Roberta Brinton |
| E-mail(s) |
rbrinton@email.arizona.edu
|
| Organization name |
University of Arizona
|
| Department |
The Center for Innovation in Brain Science
|
| Street address |
1230 N Cherry Ave, PO Box 210242
|
| City |
TUCSON |
| State/province |
Arizona |
| ZIP/Postal code |
85721 |
| Country |
USA |
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| Platforms (1) |
| GPL22396 |
Illumina HiSeq 4000 (Rattus norvegicus) |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA675652 |
| SRA |
SRP291787 |
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