|
| Status |
Public on Apr 23, 2009 |
| Title |
Lymphoid tissue specific homing of bone marrow-derived dendritic cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Because of their potent immunoregulatory capacity, dendritic cells (DCs) have been exploited as therapeutic tools to boost immune responses against tumors or pathogens, or dampen autoimmune or allergic responses. Murine bone marrow-derived DCs (BM-DCs) are the closest known equivalent of the blood monocyte-derived DCs that have been used for human therapy. Current imaging methods have proven unable to properly address the migration of injected DCs to small and deep tissues in mice and humans. This study presents the first extensive analysis of BM-DC homing to lymph nodes (and other selected tissues) after intravenous and intraperitoneal inoculation. Following intravenous delivery, DCs accumulated in the spleen, and preferentially in the pancreatic and lung-draining lymph nodes. In contrast, DCs injected intraperitoneally were found predominantly in peritoneal lymph nodes (pancreatic in particular), and in omentum-associated lymphoid tissue. This uneven distribution of BM-DCs, independent of the mouse strain and also observed within pancreatic lymph nodes, resulted in the uneven induction of an immune response in different lymphoid tissues. These data have important implications for the design of systemic cellular therapy with DCs, and in particular underlie a previously unsuspected potential for specific treatment of diseases such as autoimmune diabetes and pancreatic cancer.
This SuperSeries is composed of the SubSeries listed below.
|
| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
19363220 |
| Submission date |
Apr 22, 2009 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Remi J Creusot |
| E-mail(s) |
rcreusot@stanford.edu
|
| URL |
http://fathmanlab.stanford.edu/people/index.html
|
| Organization name |
Stanford University
|
| Department |
Medicine
|
| Lab |
Fathman
|
| Street address |
269 Campus Dr, CCSR 2240
|
| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL7042 |
Agilent-012694 Whole Mouse Genome G4122A (Probe Name version) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
|
| Samples (11)
|
| GSM394096 |
Gene expression in PLN vs MLN (BALB/c) |
| GSM394097 |
Gene expression in PLN vs ILN (FVB) |
| GSM394542 |
Gene expression in PLN vs MLN (FVB) |
| GSM394685 |
Gene expression in PLN vs ILN (NOD) |
| GSM394687 |
Gene expression in PLN vs MLN (NOD) |
| GSM394688 |
Gene expression in PLN vs ILN (NOD.B10) |
| GSM394741 |
Gene expression in PLN vs MLN (NOD.B10) |
| GSM395584 |
Gene expression in GLN vs PDLN (NOD mouse #1) |
| GSM395585 |
Gene expression in GLN vs PDLN (NOD mouse #2) |
| GSM395586 |
Gene expression in GLN vs PDLN (NOD mouse #3) |
| GSM395587 |
Gene expression in GLN vs PDLN (NOD mouse #4) |
|
| This SuperSeries is composed of the following SubSeries: |
| GSE15748 |
Gene expression in PLN vs. ILN or MLN in mice |
| GSE15753 |
Gene expression in GLN versus PDLN in NOD mice |
|
| Relations |
| BioProject |
PRJNA116859 |
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