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| Status |
Public on Apr 07, 2023 |
| Title |
Expression data from syngeneic Hepa1-6 model in C57Bl/6J mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Lenvatinib is an effective drug in advanced hepatocellular carcinoma (HCC). Its combination with the anti-PD1 immune checkpoint inhibitor pembrolizumab has achieved encouraging results in phase Ib and is currently being tested in phase III trials. Here, we aimed at exploring the molecular and immunomodulatory effects of lenvatinib alone or in combination with anti-PD1.
We generated a syngeneic model of HCC in C57BL/6J mice and randomized the animals to receive placebo, lenvatinib, anti-PD1 or combination treatment. Transcriptomic analysis were performed to assess the expression profile of tumors from mice receiving each treatment strategy.
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| Overall design |
Tumors were collected 13 days post-randomization. Animals were euthanized 1 day after the last anti-PD1 dose and 2h after the last lenvatinib dose in accordance with pharmacodynamic studies (n=21). Gene expression analyses were conducted using the Clariom S Mouse Array (Affymetrix).
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| Contributor(s) |
Torrens L, Llovet JM |
| Citation(s) |
34157147 |
| Submission date |
Jun 24, 2020 |
| Last update date |
Apr 08, 2023 |
| Contact name |
Laura Torrens |
| E-mail(s) |
ltorrens@clinic.cat
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| Organization name |
IDIBAPS, Hospital Clínic Barcelona
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| Street address |
Esther Koplowitz Center, 3rd Floor. C/ Rosselló 149-153
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| City |
Barcelona |
| State/province |
Barcelona |
| ZIP/Postal code |
08036 |
| Country |
Spain |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (21)
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| GSM4635704 |
Placebo treatment arm, mouse 4 |
| GSM4635705 |
Placebo treatment arm, mouse 5 |
| GSM4635706 |
Placebo treatment arm, mouse 6 |
| GSM4635707 |
Lenvatinib treatment arm, mouse 1 |
| GSM4635708 |
Lenvatinib treatment arm, mouse 2 |
| GSM4635709 |
Lenvatinib treatment arm, mouse 3 |
| GSM4635710 |
Lenvatinib treatment arm, mouse 4 |
| GSM4635711 |
Lenvatinib treatment arm, mouse 5 |
| GSM4635712 |
Anti-PD1 treatment arm, mouse 1 |
| GSM4635713 |
Anti-PD1 treatment arm, mouse 2 |
| GSM4635714 |
Anti-PD1 treatment arm, mouse 3 |
| GSM4635715 |
Anti-PD1 treatment arm, mouse 4 |
| GSM4635716 |
Anti-PD1 treatment arm, mouse 5 |
| GSM4635717 |
Combination treatment arm, mouse 1 |
| GSM4635718 |
Combination treatment arm, mouse 2 |
| GSM4635719 |
Combination treatment arm, mouse 3 |
| GSM4635720 |
Combination treatment arm, mouse 4 |
| GSM4635721 |
Combination treatment arm, mouse 5 |
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| Relations |
| BioProject |
PRJNA641716 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE153203_RAW.tar |
21.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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