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| Status |
Public on Sep 21, 2020 |
| Title |
Transcriptomic and epigenomic profiling of H3K27me3 demethylases inhibitor GSK-J4 induced changes in colon cancer cells (RNA-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
H3K27me3 demethylases UTX and JMJD3 play vital roles in development and disease, including cancer. Therefore, we systematically investigated the impact of inhibition of these two demethylases using a small molecule inhibitor in colon cancer cells.
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| Overall design |
HCT116 colon cancer cells were treated with 15 μm GSK-J4 or veichle for 48 hours and the cells were harvested for analysis as described below.
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| Contributor(s) |
Shu X |
| Citation(s) |
32929331 |
| Submission date |
Mar 09, 2020 |
| Last update date |
Sep 21, 2020 |
| Contact name |
Xingsheng Shu |
| E-mail(s) |
shuxingsheng@gmail.com
|
| Organization name |
Shenzhen University
|
| Department |
Health Science Center
|
| Street address |
No 3688, Nanhai Avenue
|
| City |
Shenzhen |
| State/province |
Guangdong |
| ZIP/Postal code |
518060 |
| Country |
China |
| |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE146679 |
Transcriptomic and epigenomic profiling of H3K27me3 demethylases inhibitor GSK-J4 induced changes in colon cancer cells |
|
| Relations |
| BioProject |
PRJNA611606 |
| SRA |
SRP252099 |
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