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GEO help: Mouse over screen elements for information. |
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Status |
Public on Apr 21, 2023 |
Title |
A novel mouse model of hepatocellular carcinoma mediated by hepatitis B virus-specific CD8+ T cells [bulk RNA-seq] |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We used immunocompetent Fah-/- mice as the recipients and adoptively transferred HBsAg+ hepatocytes from HBs-Tg mice to replace the recipient hepatocytes (HBs-HepR). HBs-HepR mice maintained persistent HBsAg expression with chronic hepatitis and spontaneous liver fibrosis, and eventually developed HCC with a prevalence of 100%.
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Overall design |
Liver tissue mRNA profiles of B6-HepR and HBs-HepR mice after 6 months and 12 months post transfer were generated by deep sequencing using Illumina
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Contributor(s) |
Hao X, Tian Z |
Citation missing |
Has this study been published? Please login to update or notify GEO. |
Submission date |
May 03, 2019 |
Last update date |
Apr 23, 2023 |
Contact name |
Xiaolei Hao |
Organization name |
Institute of Immunology, USTC
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Street address |
huangshan Road 443
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City |
Hefei |
State/province |
Anhui |
ZIP/Postal code |
230027 |
Country |
China |
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Platforms (1) |
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Samples (18)
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GSM3746655 |
6M_B6-HepR, liver_rep4 |
GSM3746656 |
6M_HBs-HepR, liver_rep1 |
GSM3746657 |
6M_HBs-HepR, liver_rep2 |
GSM3746658 |
6M_HBs-HepR, liver_rep3 |
GSM3746659 |
6M_HBs-HepR, liver_rep4 |
GSM3746660 |
6M_HBs-HepR, liver_rep5 |
GSM3746661 |
12M_B6-HepR, liver_rep1 |
GSM3746662 |
12M_B6-HepR, liver_rep2 |
GSM3746663 |
12M_B6-HepR, liver_rep3 |
GSM3746664 |
12M_HBs-HepR, liver_rep1 |
GSM3746665 |
12M_HBs-HepR, liver_rep2 |
GSM3746666 |
12M_HBs-HepR, liver_rep3 |
GSM3746667 |
12M_HBs-HepR-T, liver_rep1 |
GSM3746668 |
12M_HBs-HepR-T, liver_rep2 |
GSM3746669 |
12M_HBs-HepR-T, liver_rep3 |
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This SubSeries is part of SuperSeries: |
GSE130945 |
A novel mouse model of hepatocellular carcinoma mediated by hepatitis B virus-specific CD8+ T cells |
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Relations |
BioProject |
PRJNA540938 |
SRA |
SRP194744 |
Supplementary file |
Size |
Download |
File type/resource |
GSE130668_RAW.tar |
4.3 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
Raw data are available in SRA |
Processed data provided as supplementary file |
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