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Series GSE130668 Query DataSets for GSE130668
Status Public on Apr 21, 2023
Title A novel mouse model of hepatocellular carcinoma mediated by hepatitis B virus-specific CD8+ T cells [bulk RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We used immunocompetent Fah-/- mice as the recipients and adoptively transferred HBsAg+ hepatocytes from HBs-Tg mice to replace the recipient hepatocytes (HBs-HepR). HBs-HepR mice maintained persistent HBsAg expression with chronic hepatitis and spontaneous liver fibrosis, and eventually developed HCC with a prevalence of 100%.
 
Overall design Liver tissue mRNA profiles of B6-HepR and HBs-HepR mice after 6 months and 12 months post transfer were generated by deep sequencing using Illumina
 
Contributor(s) Hao X, Tian Z
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Submission date May 03, 2019
Last update date Apr 23, 2023
Contact name Xiaolei Hao
Organization name Institute of Immunology, USTC
Street address huangshan Road 443
City Hefei
State/province Anhui
ZIP/Postal code 230027
Country China
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (18)
GSM3746652 6M_B6-HepR, liver_rep1
GSM3746653 6M_B6-HepR, liver_rep2
GSM3746654 6M_B6-HepR, liver_rep3
This SubSeries is part of SuperSeries:
GSE130945 A novel mouse model of hepatocellular carcinoma mediated by hepatitis B virus-specific CD8+ T cells
Relations
BioProject PRJNA540938
SRA SRP194744

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE130668_RAW.tar 4.3 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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