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| Status |
Public on May 08, 2019 |
| Title |
Malignant transformation of normal mature mouse B cells into myeloma-like cells in vitro using defined genetic elements |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Expression of MYC+BMI1+BCLXL in normal mature mouse B cells results inmalignant transformation into lymphoma-like cells
Expression of MYC+BMI1+BCLX+IRF4 in normal mature mouse B cells results in malignant transformation into myeloma-like cells
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| |
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| Overall design |
Retroviral transduction of lipopolysaccharide-stimulated B cells in vitro. The 7 cells tested are biological replicates.
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| |
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| Contributor(s) |
Grandien A, Högstrand K, Lindvall JM, Sundblad A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 24, 2018 |
| Last update date |
May 09, 2019 |
| Contact name |
Jessica Margareta Lindvall |
| E-mail(s) |
jessica.lindvall@nbis.se
|
| Organization name |
SciLifeLab. Stockholm University
|
| Department |
NBIS
|
| Street address |
Tomtebodavägen 23A
|
| City |
Solna |
| ZIP/Postal code |
11111 |
| Country |
Sweden |
| |
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| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
|
| Samples (7)
|
| GSM3487642 |
Spleen_transformed_Bcell_lymphoma-like_Rep1 |
| GSM3487643 |
Spleen_transformed_Bcell_lymphoma-like_Rep2 |
| GSM3487644 |
Spleen_transformed_Bcell_lymphoma-like_Rep3 |
| GSM3487645 |
Spleen_transformed_Bcell_myeloma-like_Rep1 |
| GSM3487646 |
Spleen_transformed_Bcell_myeloma-like_Rep2 |
| GSM3487647 |
Spleen_transformed_Bcell_myeloma-like_Rep3 |
| GSM3487648 |
Spleen_transformed_Bcell_myeloma-like_Rep4 |
|
| Relations |
| BioProject |
PRJNA506789 |
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