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| Status |
Public on Jan 08, 2009 |
| Title |
Role of inherent strain differences in prenatally induced differential metabolic syndrome phenotype and gene expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
There is much evidence suggesting that gene-environment interactions underlying the developmental origins of the metabolic syndrome. Previously, we have induced a metabolic syndrome phenotype in mice though prenatal undernutrition; however, the C57BL/6J strain exhibited significantly more metrics of the metabolic syndrome than the A/J strain.
We used microarrays to detail the global programme of gene expression underlying the strain differences in the prenatal induction of the adult development of the metabolic syndrome. We focused on liver function and gene expression because of it's centrol role in many aspects of the metabolic syndrome including glucose and lipid control.
Keywords: disease state analysis between mouse strains
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| Overall design |
Pregnant A/J and C57BL/6J mice were either exposed to prenatal undernutrition during pregnancy or control conditions. The livers from 32 male offspring (8 per group within each of the two strains) were dissected out at 7 months of age and total RNA was extracted and hybridization on Affymetrix microarrays.
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| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 15, 2008 |
| Last update date |
Mar 04, 2019 |
| Contact name |
brian knight |
| E-mail(s) |
bknight@mshri.on.ca
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| Phone |
4165868224
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| Organization name |
samuel lunenfeld research institute
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| Street address |
25 orde st
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| City |
toronto |
| ZIP/Postal code |
m5s3a6 |
| Country |
Canada |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (32)
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| Relations |
| BioProject |
PRJNA113519 |
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