|
| Status |
Public on Nov 13, 2018 |
| Title |
Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Maresin 1 administered to mice prior to orthopedic surgery exerts distinct anti-inflammatory and pro-resolving effects through regulation of MΦ infiltration, NF-κB signaling, and cytokine release.
We used microarrays to detail the global programme of gene expression underlying Maresin 1 effect on mouse hippocampus and identified distinct classes of dysregulated genes during this process.
|
| |
|
| Overall design |
Mice hippocampi were isolated 72 h after surgery and RNA was extracted for further processing and hybridization on Affymetrix microarray.
|
| Web link |
https://doi.org/10.1016/j.bja.2018.10.062
|
| |
|
| Contributor(s) |
Mkrtchian S, Terrando N |
| Citation(s) |
30770053, 35116043 |
| Submission date |
Jun 07, 2018 |
| Last update date |
Feb 08, 2022 |
| Contact name |
Souren Mkrtchian |
| E-mail(s) |
souren.mkrtchian@ki.se
|
| Phone |
+46739586763
|
| Organization name |
Karolinska Institutet
|
| Department |
Physiology and Pharmacology
|
| Lab |
Section of Anesthesiology
|
| Street address |
Solnavägen 9
|
| City |
Stockholm |
| ZIP/Postal code |
17177 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA475007 |
Less...
More...