|
| Status |
Public on Jun 30, 2018 |
| Title |
The functions of KDM5A in regulation of p53 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We reveal that the histone demethylase KDM5A suppresses p53 activity by inhibiting its translation initiation.
|
| |
|
| Overall design |
Biological duplicate samples were treated with siRNA for 72 hours.
|
| |
|
| Contributor(s) |
Yang J |
| Citation(s) |
30388705 |
| Submission date |
Jun 26, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
JUN YANG |
| E-mail(s) |
jun.yang2@stjude.org
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Surgery
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (8)
|
| GSM2685751 |
siRNA control biological rep1 in p53+/+ HCT116 |
| GSM2685752 |
siRNA control biological rep2 in p53+/+ HCT116 |
| GSM2685753 |
siRNA KDM5A biological rep1 in p53+/+ HCT116 |
| GSM2685754 |
siRNA KDM5A biological rep2 in p53+/+ HCT116 |
| GSM2685755 |
siRNA control biological rep1 in p53-/- HCT116 |
| GSM2685756 |
siRNA control biological rep2 in p53-/- HCT116 |
| GSM2685757 |
siRNA KDM5A biological rep1 in p53-/- HCT116 |
| GSM2685758 |
siRNA KDM5A biological rep2 in p53-/- HCT116 |
|
| Relations |
| BioProject |
PRJNA391977 |
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