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TAG1 membrane bound O-acyl transferase (MBOAT) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816464, updated on 7-Sep-2023

Summary

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Gene symbol
TAG1
Gene description
membrane bound O-acyl transferase (MBOAT) family protein
Primary source
Araport:AT2G19450
Locus tag
AT2G19450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ABX45; acyl-CoA:diacylglycerol acyltransferase 1; Arabidopsis thaliana acyl-CoA:diacylglycerol acyltransferase; AS11; ATDGAT; AtDGAT1; DGAT1; DIACYLGLYCEROL ACYLTRANSFERASE; F27F23.24; RDS1; TRIACYLGLYCEROL BIOSYNTHESIS DEFECT 1
Summary
Encodes Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the final step of the triacylglycerol synthesis pathway. An insertion mutation in the TAG1 gene results in altered lipid phenotype. Role in senescence and seed development. Its preferred substrate is linolenoyl-CoA (C18:3-CoA).
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Genomic context

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Location:
chromosome: 2
Exon count:
16
Sequence:
Chromosome: 2; NC_003071.7 (8426117..8429853)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1 Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene DUF3511 domain protein (DUF3511) Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo packaging of triacylglycerols enhances Arabidopsis leaf biomass and energy density. Winichayakul S, et al. Plant Physiol, 2013 Jun. PMID 23616604, Free PMC Article
  2. A role for diacylglycerol acyltransferase during leaf senescence. Kaup MT, et al. Plant Physiol, 2002 Aug. PMID 12177474, Free PMC Article
  3. Arabidopsis mutants deficient in diacylglycerol acyltransferase display increased sensitivity to abscisic acid, sugars, and osmotic stress during germination and seedling development. Lu C, et al. Plant Physiol, 2002 Jul. PMID 12114588, Free PMC Article
  4. Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight. Jako C, et al. Plant Physiol, 2001 Jun. PMID 11402213, Free PMC Article
  5. The TAG1 locus of Arabidopsis encodes for a diacylglycerol acyltransferase. Routaboul JM, et al. Plant Physiol Biochem, 1999 Nov. PMID 10580283

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. On the Role of DGAT1 in Seed Glycerolipid Metabolic Network and Critical Stages of Plant Development in Arabidopsis.
    Title: On the Role of DGAT1 in Seed Glycerolipid Metabolic Network and Critical Stages of Plant Development in Arabidopsis.
  2. Oil-Producing Metabolons Containing DGAT1 Use Separate Substrate Pools from those Containing DGAT2 or PDAT.
    Title: Oil-Producing Metabolons Containing DGAT1 Use Separate Substrate Pools from those Containing DGAT2 or PDAT.
  3. The conversion of diacylglycerol to triacylglycerol by DGAT1 is critical for plant freezing tolerance.
    Title: DIACYLGLYCEROL ACYLTRANSFERASE and DIACYLGLYCEROL KINASE Modulate Triacylglycerol and Phosphatidic Acid Production in the Plant Response to Freezing Stress.
  4. DGAT1 expression is regulated by MYB96 in the Arabidopsis seeds.
    Title: The MYB96 Transcription Factor Regulates Triacylglycerol Accumulation by Activating DGAT1 and PDAT1 Expression in Arabidopsis Seeds.
  5. The constructed promoter was ligated upstream of the TAG1 gene encoding diacylglycerol acyltransferase 1 and introduced into Arabidopsis. Seeds from transgenic plants carrying AtTAG1 under the control of the chimeric promoter showed increased oil content (up by 1873%) compared with wild-type seeds.
    Title: Design of a Seed-Specific Chimeric Promoter with a Modified Expression Profile to Improve Seed Oil Content.
  6. This study identifies the first two regulatory genes, WRI1 and DGAT1, that control the synthesis of all tocochromanol forms in seeds, and shows the existence of a metabolic trade-off between lipid and tocochromanol metabolisms.
    Title: WRINKLED1 and ACYL-COA:DIACYLGLYCEROL ACYLTRANSFERASE1 regulate tocochromanol metabolism in Arabidopsis.
  7. The results suggest that dedifferentiation is associated with Tag1 activation and that CMT3 rather than DDM1 plays a central role in restraining Tag1 activation via inducing gene body DNA methylation.
    Title: Activation of Tag1 transposable elements in Arabidopsis dedifferentiating cells and their regulation by CHROMOMETHYLASE 3-mediated CHG methylation.
  8. ABI4 and ABI5 synergistically regulate DGAT1 expression in Arabidopsis seedlings under stress.
    Title: ABA-insensitive (ABI) 4 and ABI5 synergistically regulate DGAT1 expression in Arabidopsis seedlings under stress.
  9. Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2.
    Title: Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2.
  10. ABI4 is essential for the activation of DGAT1 in Arabidopsis seedlings during nitrogen deficiency.
    Title: ABI4 activates DGAT1 expression in Arabidopsis seedlings during nitrogen deficiency.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_127503.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables diacylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacylglycerol O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables diacylglycerol O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
membrane bound O-acyl transferase (MBOAT) family protein
NP_179535.1
  • TRIACYLGLYCEROL BIOSYNTHESIS DEFECT 1 (TAG1); CONTAINS InterPro DOMAIN/s: Membrane bound O-acyl transferase, MBOAT (InterPro:IPR004299); Has 951 Blast hits to 945 proteins in 279 species: Archae - 0; Bacteria - 104; Metazoa - 315; Fungi - 305; Plants - 83; Viruses - 0; Other Eukaryotes - 144 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    8426117..8429853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127503.3 → NP_179535.1  membrane bound O-acyl transferase (MBOAT) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179535.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9S7F2, Q9SLD2
    UniProtKB/TrEMBL
    A0A178VVE4, A0A5S9WZA8
    Conserved Domains (1) summary
    PLN02401
    Location:101 → 519
    PLN02401; diacylglycerol o-acyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SLD2.2

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