human[organism] AND (smok* OR diet) - GEO DataSets

Search results

Items: 1 to 20 of 99650

<< First< Prev

Page of 4983

Select item 2002456991.

High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility

(Submitter supplied) Genome-wide association studies (GWAS) have identified multiple lung cancer risk loci including those that are distinct in the major histological types. However, most of these loci have not been functionally characterized. Here we employed massively parallel reporter assays (MPRA) to assess allelic transcriptional activity of risk-associated variants en masse. We tested 2,245 variants in 42 loci from 3 recent GWASs of East Asian and European populations in the context of lung adenocarcinoma and squamous cell carcinoma cells while incorporating exposure to a tobacco-smoke carcinogen, benzo[a]pyrene. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
22 Samples

Download data: TXT

Series

Accession:: GSE245699

ID:: 200245699

Select item 2002534152.

GLI1+ cells contribute to vascular remodeling in hypoxia- and cigarette smokeinduced pulmonary hypertension

(Submitter supplied) The precise origin of newly formed alpha smooth muscle actin-positive (ACTA2+) cells appearing in non-muscularized vessels in the context of pulmonary hypertension (PH) is still debatable, although it is believed that they predominantly derive from pre-existing vascular smooth muscle cells (VSMCs). Here, Gli1Cre-ERT2; tdTomatoflox mice were used to lineage-trace GLI1+ cells in the context of PH using two independent models of vascular remodeling (VR) and reverse remodeling (RR): Hypoxia and cigarette-smoke exposure (SE). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: CSV

Series

Accession:: GSE253415

ID:: 200253415

Select item 2002338443.

Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis

(Submitter supplied) Rationale: Changes in peripheral blood cell populations have been observed but not detailed at single-cell resolution in idiopathic pulmonary fibrosis (IPF). Objectives: To provide an atlas of the changes in the peripheral immune system in stable and progressive IPF. Methods: Peripheral blood mononuclear cells (PBMCs) from IPF patients and controls were profiled using 10x Chromium 5’ single-cell RNA sequencing (scRNA-seq). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
38 Samples

Download data: MTX, TSV

Series

Accession:: GSE233844

ID:: 200233844

Select item 2002458864.

Analyses of lncRNA and mRNA profiles in the recurrent atrial fibrillation after Catheter Ablation

(Submitter supplied) Our study aims to elucidate the role of lncRNA-mRNA regulatory networks in AF recurrence after catheter ablation. We performed RNA sequencing to profile the transcriptomes of 5 samples from atrial fibrillation recurrence and 5 samples from sinus rhythm maintenance. 96 differentially expressed genes (DEGs) and 203 differentially expressed long non-coding RNAs (DE-lncRNAs) were identified between atrial fibrillation recurrence group and sinus rhythm maintenance group. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
10 Samples

Download data: TXT

Series

Accession:: GSE245886

ID:: 200245886

PubMed Full text in PMC Similar studies

Select item 2002241245.

Whole-Genome Methylation Profiling Reveals Regions Associated with Painful Temporomandibular Disorders and Active Recovery Processes

(Submitter supplied) Genome wide DNA methylation profiling of samples with/without chronic or acute Temporomandibular Disorders (TMD). The Illumina Infinium Human methylationEPIC Beadchip was used to obtain DNA methylation profiles across 1,051,943 CpGs in TMD samples. Samples included 452 non-TMD and 496 chronic TMD from OPPERA I, 36 healthy and 123 acute TMD from OPPERA II.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
1107 Samples

Download data: CSV, IDAT

Series

Accession:: GSE224124

ID:: 200224124

PubMed Similar studies

Select item 2002477426.

RNA sequencing of sort-purified ILC3s from IBD patients

(Submitter supplied) Group 3 innate lymphoid cells (ILC3s) are abundant in the developing or healthy intestine to critically support tissue homeostasis in response to microbial cues and other environmental signals. However, during gastrointestinal disease including infections, colorectal cancer, or inflammatory bowel disease (IBD), intestinal ILC3 numbers are dramatically reduced and the remaining ILC3s become dysfunctional which fuels disease and barrier breakdown. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
14 Samples

Download data: TXT

Series

Accession:: GSE247742

ID:: 200247742

Select item 2002406567.

Multi-center Korean cohort study based on RNA-sequencing data targeting COPD patients

(Submitter supplied) To determine gene expression changes that contribute to the development of COPD among smokers using high-throughput RNA sequencing in the peripheral blood of COPD patients. Total RNA sequencing was investigated by prospectively collecting lung function test results and whole blood samples from smokers who visited the outpatient department of respiratory medicine at three hospitals since 2020. This study confirmed gene expression differences in non-coding RNA in COPD patients according to the degree of airflow limitation through RNA-Seq transcriptome analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL30209
294 Samples

Download data: TXT

Series

Accession:: GSE240656

ID:: 200240656

Select item 2002613488.

Spatially preserved multi-region transcriptomic subtyping and biomarkers of outcome with chemoimmunotherapy in extensive-stage small cell lung cancer [IMfirst_DSP cohort]

(Submitter supplied) Transcriptomic subtyping holds promise for personalized therapy in extensive stage small cell lung cancer (ES-SCLC). In this study, we aimed to assess intratumoral transcriptomic subtype diversity and to identify biomarkers associated with long-term chemoimmunotherapy benefit in human ES-SCLC. Our work highlights that high intratumoral heterogeneity, lack of consistent association with outcome, and unclear subtype-specific target expression are major challenges for SCLC subtype-based precision oncology. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL30173
175 Samples

Download data: DCC, PKC, PNG, XLSX

Series

Accession:: GSE261348

ID:: 200261348

Select item 2002613459.

Spatially preserved multi-region transcriptomic subtyping and biomarkers of outcome with chemoimmunotherapy in extensive-stage small cell lung cancer [CANTABRICO_DSP cohort]

Organism:: Homo sapiens

Type:: Other

Platform:: GPL30173
121 Samples

Download data: DCC, PKC, PNG, XLSX

Series

Accession:: GSE261345

ID:: 200261345

Select item 20023981510.

Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

(Submitter supplied) Spermatozoa harbor a complex and environment sensitive pool of small non-coding RNAs (sncRNA)1, which influences offspring development and adult phenotypes1-7. Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood8. We used two distinct paradigms of preconception acute high fat diet to dissect epididymal vs testicular contributions to the sperm sncRNA pool and offspring health. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL17021 GPL24676 GPL24247
307 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE239815

ID:: 200239815

Select item 20023981011.

Mitochondrial signals mediate paternal effects on offspring metabolism (small RNA-Seq)

(Submitter supplied) Spermatozoa deliver a complex and environment sensitive pool of small non-coding RNAs (sncRNA) to the oocyte at fertilisation, which influences offspring development and adult phenotypic trajectories. Whether mature spermatozoa in the epididymis can directly sense the environment is still not fully understood. Here, we used two distinct paradigms of preconception acute High Fat Diet challenge to dissect epididymal vs spermatogenic contributions to the sperm sncRNA pool and offspring health. more...

Organism:: Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247
44 Samples

Download data: TXT

Series

Accession:: GSE239810

ID:: 200239810

Select item 20022936212.

microRNA signature to support clinical-decision making in patients with suspected Obstructive Sleep Apnea

(Submitter supplied) Plasmatic microRNA sequencing was conducted in specific matched subgroups of subjects (n = 53) with and without OSA using HTG EdgeSeq miRNA WTA Assay technology.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
53 Samples

Download data: TXT

Series

Accession:: GSE229362

ID:: 200229362

Select item 20022628013.

Transcriptome data of monocytes from adolescents with obesity and age / sex matched controls

(Submitter supplied) Trained immunity is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to certain microbial components, diets, or metabolites, altering their responses to future exposures. Trained immunity is observed in hypercholesterolemia, dislipidemia, and in response to high fat diet. In this study monocytes from obese adolescents and controls were exposed to microbial stimulation in vitro or media alone, and transcriptional profiles were generated.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
22 Samples

Download data: TXT

Series

Accession:: GSE226280

ID:: 200226280

Analyze with GEO2R

Select item 20024037014.

Transcriptomic analysis of the in vivo effects of CDK8/19 inactivation in 22Rv1 xenografts growing in intact and castrated NSG mice

(Submitter supplied) RNA-Seq analysis was carried out to investigate the effects of CDK8/19 inactivation in the tumors formed in intact and castrated NSG mice by different 22Rv1 derivatives, with or without SNX631 treatment. The 22Rv1 derivatives were generated as following: Parental 22Rv1 (Rv1-WT) were transduced with a lentivirus expressing luciferase, yielding the derivative Rv1-Luc. 22Rv1 cells with a double knockout of CDK8 and CDK19 (Rv1-dKO) were made via CRISPR/Cas9. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
66 Samples

Download data: TXT

Series

Accession:: GSE240370

ID:: 200240370

Select item 20025216915.

Epigenome-wide profiling of buccal DNAm in samples obtained from children of pregnant smokers enrolled in the VCSIP RCT: NCT03203603

(Submitter supplied) DNA methylation analysis was performed for buccal samples from children exposed in utero to maternal smoking during pregnancy (with or without vitamin C supplementation) and in a smaller number of non-smoker controls

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
359 Samples

Download data: IDAT, TXT

Series

Accession:: GSE252169

ID:: 200252169

Select item 20025224316.

IMMUNE-RESPONSIVE GENE 1 REGULATES ATHEROSCLEROTIC PLAQUE INFLAMMATION

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE252243

ID:: 200252243

PubMed Full text in PMC Similar studies

Select item 20026120517.

A network-based framework to discover treatment-response-predicting biomarkers for complex diseases

(Submitter supplied) Precision medicine's potential to transform complex autoimmune-disease treatment is often challenged by limited data availability and inadequate sample size when compared to the number of molecular features found in high-throughput multi-omics datasets. Addressing this issue, the novel framework PRoBeNet (Predictive Response Biomarkers using Network medicine) was developed. ProBeNet operates under the hypothesis that the therapeutic effect of a drug propagates through a protein–protein interaction network to reverse disease states. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: CSV

Series

Accession:: GSE261205

ID:: 200261205

Select item 20017454318.

Genome-wide RNAseq of liver tissue derived from humanized mice fed by CDA-HFD and treated with CLDN1 mAb or vehicle Control

(Submitter supplied) Six-week old Fah−/−/Rag2−/−/Il2rg −/− (FRG) –NOD breeding mice were intravenously injected with 1.5 x 10^9 plaque forming units (pfu) of an adenoviral vector encoding the secreted form of the human urokinase-like plasminogen activator (Ad-uPA). Forty-eight hours later, 10^6 PHH were injected intrasplenically. Successfully transplanted mice were fed with CDA-HFD for 16 weeks and then treated with humanized CLDN1 specific mAb 500 µg or vehicle for additional 8 weeks. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25431
10 Samples

Download data: TSV

Series

Accession:: GSE174543

ID:: 200174543

SRA Run Selector

Select item 20025609219.

Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations [MethylationEPIC]

(Submitter supplied) Never-smoker lung adenocarcinoma (NSLA) is prevalent in Asian populations, and is even more in women. EGFR mutations and ALK fusions are major alterations observed in NSLA. We have focused on NSLA without EGFR and ALK alteration (NENA) rather than NSLA with EGFR and ALK (EA). First, we selected 141 NSLA tissues, and performed proteogenomic analyses including the whole-genome sequencing (WGS), transcriptome, methylation EPIC array, total proteome and phosphoproteome. more...