Similar studies for GEO DataSets (Select 4972) - GEO DataSets

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Items: 19

Select item 49721.

Laccaic acid effect on breast cancer cell line

Analysis of MCF-7 breast cancer cells treated with laccaic acid A (LCA). LCA, a highly substituted anthraquinone natural product, is a small molecule inhibitor of DNA methyltransferase 1 (Dnmt1). Results provide insight into the degree of selectiveness of LCA’s inhibitory activity on Dnmt1.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL6244
Series:: GSE45804
6 Samples

Download data: CEL

DataSet

Accession:: GDS4972

ID:: 4972

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000458042.

Gene expression data from MCF-7 cells treated with Lacciac Acid A

(Submitter supplied) Lacciac Acid A was indentified as an inhibitor of DMNT1. MCF-7 cells were treated with Lacciac Acid A (200 uM) for 5 days. Changes in gene expression were identified by using Affymetrix Human gene ST1.0 arrays. We used microarrays to determine global changes in gene expression upon treatment with Lacciac Acid A an inhibitor of DMNT1.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4972
Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE45804

ID:: 200045804

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000551253.

Aza treated AML3 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL11154 GPL10999
10 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE55125

ID:: 200055125

PubMed Full text in PMC Similar studies

Select item 2000551244.

Genome-wide methylation maps for untreated and Aza treated AML3 cells

(Submitter supplied) AML3 cells were treated with Azacytidine and compared against untreated cells

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE55124

ID:: 200055124

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000551235.

Expression data from untreated and Aza treated AML3 cells

(Submitter supplied) AML3 cells were treated with Azacytidine and compared against untreated cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10999
6 Samples

Download data: BIGWIG

Series

Accession:: GSE55123

ID:: 200055123

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000152006.

Effects of DZNep and 5-Aza-CdR on gene expression in MCF7 cells after 72 h treatment

(Submitter supplied) DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor related genes in cancer. The development of drugs that target these processes is therefore important for cancer therapy. Inhibitors of DNA methylation and histone deacetylation have already been approved by the FDA for the treatment of hematologic malignancies. However, drugs that target the other mechanisms still need to be developed. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6102
6 Samples

Download data: CSV

Series

Accession:: GSE15200

ID:: 200015200

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000137337.

Effects of DZNep and 5-Aza-CdR on gene expression in MCF7 cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
10 Samples

Download data: CSV

Series

Accession:: GSE13733

ID:: 200013733

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000417548.

Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL10558 GPL13534
32 Samples

Download data

Series

Accession:: GSE41754

ID:: 200041754

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000416769.

Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (gene expression)

(Submitter supplied) A combinatorial treatment consisting of a DNMTi and a LSD1i shows synergistic effects in reactivating aberrantly silenced genes by enriching H3K4me2 and H3K4me.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
24 Samples

Download data

Series

Accession:: GSE41676

ID:: 200041676

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004152510.

Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (methylation)

(Submitter supplied) A combinatorial treatment consisting of a DNMTi and a LSD1i shows synergistic effects in reactivating aberrantly silenced genes by enriching H3K4me2 and H3K4me.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
8 Samples

Download data: TXT

Series

Accession:: GSE41525

ID:: 200041525

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001759811.

5-aza-2-deoxycytidine treatment of Swarm rat chondrosarcoma cells

(Submitter supplied) The puropose of this experiment was to identify gene expression changes that result from 5-aza-2-deoxycytidine induced DNA demethylation of Swarm rat chondrosarcoma cells. The gene expression profiles of untreated Swarm rat chondrosarcoma cells were compared to the gene expression profiles of Swarm rat chondrosarcoma cells that were treated for 5 passages with a low dose of 5-aza-2-deoxycytidine (0.1uM).

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL8990
5 Samples

Download data: PAIR

Series

Accession:: GSE17598

ID:: 200017598

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013537812.

RNA-seq of DNMT1 inhibitor treated AML cell lines

(Submitter supplied) Genome wide demethylation by DNMT1 inhibitors GSK3685032 results in up-regulation of epigenetically-silenced genes.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
156 Samples

Download data: TXT

Series

Accession:: GSE135378

ID:: 200135378

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013520713.

Expression profiling and methylation analysis of DNMT1 inhibitor treated AML cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL21145
221 Samples

Download data: IDAT

Series

Accession:: GSE135207

ID:: 200135207

PubMed Full text in PMC Similar studies

Select item 20013520614.

MethylationEPIC array of DNMT1 inhibitor treated AML cell lines - part II

(Submitter supplied) Genome wide demethylation by DNMT1 inhibitor GSK3484862 results in up-regulation of epigenetically-silenced genes. Methylation was assayed for each cell line following DNMT1 inhibitor or vehicle treatment. Global methylation distributions were compared between treated and untreated samples.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
14 Samples

Download data: IDAT, TXT

Series

Accession:: GSE135206

ID:: 200135206

PubMed Full text in PMC Similar studies

Select item 20013520515.

Epic methylation arrays of DNMT1 inhibitor treated AML cell lines

(Submitter supplied) Genome wide demethylation by DNMT1 inhibitor GSK3685032 results in up-regulation of epigenetically-silenced genes

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
51 Samples

Download data: IDAT, TXT

Series

Accession:: GSE135205

ID:: 200135205

PubMed Full text in PMC Similar studies

Select item 20005734316.

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL13534 GPL4133
575 Samples

Download data: TXT

Series

Accession:: GSE57343

ID:: 200057343

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005734217.

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers [methylation]

(Submitter supplied) Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidine (AZA). Gene Set Enrichment Analysis demonstrated significant enrichment for immunomodulatory pathways in all three cancers (14.4-31.3%) including interferon signaling, antigen processing and presentation, and cytokines/chemokines. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
338 Samples

Download data: TXT

Series

Accession:: GSE57342

ID:: 200057342

PubMed Full text in PMC Similar studies

Select item 20005734118.

Effect of AZA on gene expression of multiple breast, colon, and ovarian cell lines [expression]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
237 Samples

Download data: TXT

Series

Accession:: GSE57341

ID:: 200057341

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004593219.

Rat MeDIP Array, naïve, epileptic, and adenosine treated

(Submitter supplied) Epilepsy causes altered gene expression; transient adenosine treatment inhibits progression of epileptogenesis Hippocampus of epileptic rat is hypermethylated compared to naïve; adenosine treatment causes hypomethylation