Similar studies for GEO DataSets (Select 200232244) - GEO DataSets

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Items: 20

Select item 2002322441.

Differential Expression Data from Mice 24hrs after stroke

(Submitter supplied) Microglial activation after stroke may lead to development of inflammation-induced brain damage. Here we uncover a ribosome-based mechanism/check point involved in control of the innate immune response and microglial activation orchestrated by RNA binding protein SRSF3. Using an in vivo model-system for analysis of the dynamic translational state of microglial ribosomes with mRNAs as input and newly synthesized peptides as an output, we found a marked dissociation of microglia mRNA and protein signatures following ischemic stroke. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL, CHP, XLSX

Series

Accession:: GSE232244

ID:: 200232244

Select item 2001070342.

Differential Expression Data from Lipopolysaccharide (LPS) Injected Mice

(Submitter supplied) Uncontrolled microglial activation may lead to development of inflammation-induced brain damage. Here we uncover a ribosome-based mechanism/check point involved in control of the innate immune response and microglial activation. Using an in vivo model-system for analysis of the dynamic translational state of microglial ribosomes with mRNAs as input and newly synthesized peptides as an output, we find a marked dissociation of microglia mRNA and protein networks following innate immune challenge. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL, CHP, XLSX

Series

Accession:: GSE107034

ID:: 200107034

Select item 2001230023.

RNA-Seq analysis of SRSF3 KO hearts compared to controls and iCLIP analysis of SRSF3 binding profile in neonatal cardiomyocytes

(Submitter supplied) The goal of this study is to analyse the transcriptome of control hearts vs hearts lacking SRSF3 expression and to analyse binding preferences of SRSF3 in cardiac myocytes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: BED, XLSX

Series

Accession:: GSE123002

ID:: 200123002

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Select item 2001137944.

RNA sequencing of SRSF3 depleted pluripotent cells

(Submitter supplied) RNA seqeuncing was performed to identifiy changes in genes expression and alternative splicing following SRSF3 depletion in pluripotent stem cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
4 Samples

Download data: CSV, XLSX

Series

Accession:: GSE113794

ID:: 200113794

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Select item 2001019055.

Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming

(Submitter supplied) Somatic cell reprogramming into pluripotent stem cells (iPSC) through the forced expression of defined factors induces changes in genome architecture reflective of the embryonic stem cell state. However, only a small minority of cells typically transition to pluripotency, which has limited our understanding of what defines cells that successfully reprogram. Here, we characterize the changes that occur across the DNA regulatory landscape during reprogramming by time-course profiling of isolated sub-populations of reprogramming intermediates poised to become iPSC. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL18480
85 Samples

Download data: BED, BIGWIG, TXT, XLSX

Series

Accession:: GSE101905

ID:: 200101905

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Select item 2001419726.

TGFβ-activated kinase 1-dependent microglial and macrophage responses aggravate long-term outcomes after ischemic stroke

(Submitter supplied) Microglia/macrophages (Mi/MΦ) can profoundly influence stroke outcomes by acquiring functionally dominant phenotypes (pro-inflammatory or anti-inflammatory; neurotoxic or neuroprotective). Identification of the molecular mechanisms that dictate the functional status of Mi/MΦ after brain ischemia/reperfusion may reveal novel therapeutic targets for stroke. We hypothesized that activation of TGFβ-activated kinase 1 (TAK1), a key MAP3K upstream of multiple inflammation-regulating pathways, drives Mi/MΦ towards a pro-inflammatory phenotype and potentiates ischemia/reperfusion brain injury. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
11 Samples

Download data: TSV

Series

Accession:: GSE141972

ID:: 200141972

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Select item 2001305017.

Transcriptome-wide analysis of wild-type and SRSF3-knockout glioma stem-like cells

(Submitter supplied) Purpose: The splicing factor SRSF3 is a member of serine- and arginine-rich proteins, which is frequently upregulated in various types of cancer. The aim of this study is to profile the alternative splicing (AS) events that were regulated by SRSF3 in glioma stem-like cells (GSCs). Methods: Total RNAs isolated from GSC83 and GSC528 cells with SRSF3-konckout (KO) or control (WT) were subjected to paired-end RNA-seq using the Illumina NextSeq 500 system according to the manufacturer's instruction. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: TXT

Series

Accession:: GSE130501

ID:: 200130501

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Select item 2001556208.

RNA Binding Protein SRSF3 confers an essential role in megakaryocyte maturation and platelet production

(Submitter supplied) RNA sequencing was performed to identify gene expression changes following SRSF3 depletion in mouse bone marrow megakaryocytes and peripheral blood platelets.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18635 GPL18480
22 Samples

Download data: XLSX

Series

Accession:: GSE155620

ID:: 200155620

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Select item 2000869419.

Infiltrating monocyte-derived macrophages polarizes in to anti-inflammatory and neuro-protective phenotype in a rat model of cerebral ischemia

(Submitter supplied) To summarize our results, we found microglia and MDMs are functionally heterogeneous population contributing differently to the disease phenotype. Our data, suggest that during post-ischemic inflammation microglia exhibit pro-inflammatory phenotype, while infiltrating MDMs display anti-inflammatory and neuro-protective phenotype. Apart from up-regulation of some of the classical M2 marker in MDMs, our gene expression profiling using RNA-sequencing revealed a unique signature of MDMs with the up-regulation of genes associated with wound healing, MHCII antigen-presentation and tissue repair. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18404
21 Samples

Download data: TXT

Series

Accession:: GSE86941

ID:: 200086941

PubMed Similar studies SRA Run Selector

Select item 20016556410.

Genome-wide analysis of PGC-1α-binding in microglia

(Submitter supplied) PGC-1α in microglia protects against ischemia-induced brain damage in mice. The data suggest that microglia-specific PGC-1α play a key role in limiting ischemia-induced brain damage and potently participates in regulating microglial function. To further clarify the mechanism of PGC-1α, we conducted chromatin immunoprecipitation-sequencing (ChIP-Seq) analysis to identify the targets of PGC-1α in microglia from mPGC-1α mice at 24 h after ischemic stroke. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: WIG

Series

Accession:: GSE165564

ID:: 200165564

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015287111.

Gene expression profiles in microglia with or without PGC-1α overexpression after acute ischemic stroke (AIS)

(Submitter supplied) PGC-1α overexpression in microglia protects against ischemia-induced brain damage in mice. To investigate the underlying mechanism of PGC-1α, we have employed whole mRNA microarray expression profiling as a discovery platform to identify genes with the potential to change the microglial function. Indeed, PGC-1α overexpression alters the gene expression profiles of microglia after AIS, this suggested that microglial PGC-1α might play an important role after ischemic stroke.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
6 Samples

Download data: TXT

Series

Accession:: GSE152871

ID:: 200152871

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Select item 20015276912.

Gene expression profiles in BV2 cells with or without PGC-1α overexpression after LPS stimulation

(Submitter supplied) PGC-1α overexpression in microglia protects against ischemia-induced brain damage in mice. To investigate the underlying mechanism of PGC-1α in vitro, we have employed whole mRNA microarray expression profiling as a discovery platform to identify genes with the potential to change the BV2 cells function. Indeed, PGC-1α overexpression alters the gene expression profiles of BV2 cells, this revealed that PGC-1α could inhibit the production of IL-1β and pro-inflammatory cytokines.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
6 Samples

Download data: TXT

Series

Accession:: GSE152769

ID:: 200152769

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Select item 20012487413.

Gene expression profiles in microglia with or without PGC-1α overexpression

(Submitter supplied) PGC-1α overexpression in microglia protects against ischemia-induced brain damage in mice. To investigate the underlying mechanism of PGC-1α, we have employed whole mRNA microarray expression profiling as a discovery platform to identify genes with the potential to change the microglial function. Indeed, PGC-1α overexpression alters the gene expression profiles of microglia, this suggested that microglial PGC-1α might play an important role after ischemic stroke.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21810
6 Samples

Download data: TXT

Series

Accession:: GSE124874

ID:: 200124874

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Select item 20010501114.

Transcriptomic analysis of CD11b+ DsRed+ CD45hi cells harvested from the ischemic brain of Selplg-KODsRed → WT chimeras and Selplg-WTDsRed→ WT chimeras at 7 days after 30 min MCAo/reperfusion

(Submitter supplied) In order to assess whether PSGL-1 (SELPLG) deficiency impacts key characteristics of invading cells in our stroke model, we performed a detailed transcriptomic analysis of retrovirally transduced CD11b+ CD45hi cells harvested from the ischemic brain at 7 days after MCAo

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL24125
8 Samples

Download data: TXT

Series

Accession:: GSE105011

ID:: 200105011

Select item 20006481115.

Gene expression profiling of resident microglia and invading macrophages

(Submitter supplied) Microglia represent the resident immune cells of the central nervous system. However, blood-borne monocytic cells are also able to invade the ischemic brain. In this study, we aim to characterize similarities and differences between these two cell populations using gene expression profiling.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
8 Samples

Download data: TXT

Series

Accession:: GSE64811

ID:: 200064811

Select item 20010798316.

Ischemia/Reperfusion Induces Interferon-Stimulated Gene Expression in Microglia

(Submitter supplied) Stroke is the fifth leading cause of death in the United States and is a leading cause of serious long-term disability worldwide. Innate immune responses are critical in stroke pathophysiology, and microglia are key cellular effectors in the CNS response to ischemia/reperfusion. Using a transcriptional analysis approach, we identified a robust interferon (IFN)-stimulated gene response within microglia exposed to ischemia/reperfusion. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
14 Samples

Download data: CEL

Series

Accession:: GSE107983

ID:: 200107983

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015172417.

iCLIP-seq, RNA-seq and MACE-seq studies in P19 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL19057
46 Samples

Download data

Series

Accession:: GSE151724

ID:: 200151724

PubMed Full text in PMC Similar studies

Select item 20015172218.

MACE-seq of P19 cells after knockdown of Srsf3 and Srsf7

(Submitter supplied) Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which determines the length of their 3’ untranslated regions (3’UTRs). APA regulates stage- and tissue-specific gene expression by affecting the stability, subcellular localization and translation rate of transcripts. We have recently shown that SRSF3 and SRSF7, two closely related SR proteins, connect APA with mRNA export. more...