Similar studies for GEO DataSets (Select 200174592) - GEO DataSets

Select item 2001745921.

(Submitter supplied) MCF7 cells were infected with lentiviral particles containing LIFR-targeted shRNAs then chemically selected to create a stable pooled population of shLIFR MCF7 cells. The goal of the study was to determine the downstream targets of LIFR in human MCF7 breast cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: XLSX

Series

Accession:: GSE174592

ID:: 200174592

Select item 2001632492.

Targeted inhibition of LIFR enhances therapeutic efficacy of HDAC inhibitors in triple negative breast cancer

(Submitter supplied) Here, we examined the therapeutic utility of EC359 in improving the therapeutic efficacy of HDACi in TNBC models. BT-549 cells were treated with vehicle (DMSO), EC359, HDACi(Vorinostat), EC359+HDACi and the RNA was isolated and utilized for RNA-seq analysis. Our results demonstrated that the beneficial effect of the EC359+HDACi involves regulation of multiple genes that involved in several pathways including apoptosis, metabolism and cell cycle.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
8 Samples

Download data: TXT

Series

Accession:: GSE163249

ID:: 200163249

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000046613.

Oncostatin M Regulation of Gene Expression in Breast Tumour Cells.

(Submitter supplied) Oncostatin m (OSM) induces potent growth inhibitory and morphogenic responses in several different tumour cell types but the genetic events are not well understood. OSM can signal through two separate heterodimeric receptor complexes, gp130/LIFRα and gp130/OSMRβ. In this investigation we utilised cytokines, oncostatin M, interleukin-6 (IL-6) and leukaemia inhibitory factor (LIF) and LIF receptor antagonist, LIF-05, to help identify patterns of gene expression elicited by the different IL-6 receptor complexes in breast tumour cell line, T47D . more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL996
28 Samples

Download data: GPR, XLS

Series

Accession:: GSE4661

ID:: 200004661

Select item 2001187444.

Identification of Jun loss that promotes resistance to HDAC inhibitor Entinostat through Myc signaling in Luminal breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Genome variation profiling by array

Platforms:: GPL11383 GPL10481 GPL4092
71 Samples

Download data: TXT

Series

Accession:: GSE118744

ID:: 200118744

PubMed Full text in PMC Similar studies

Select item 2001187435.

Identification of Jun loss that promotes resistance to HDAC inhibitor Entinostat through Myc signaling in Luminal breast cancer [CGH]

(Submitter supplied) The histone deacetylase inhibitor Entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.

Organism:: Mus musculus

Type:: Genome variation profiling by array

Platform:: GPL4092
22 Samples

Download data: TXT

Series

Accession:: GSE118743

ID:: 200118743

PubMed Full text in PMC Similar studies

Select item 2001187416.

Identification of Jun loss that promotes resistance to HDAC inhibitor Entinostat through Myc signaling in Luminal breast cancer [cell line]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10481
22 Samples

Download data: TXT

Series

Accession:: GSE118741

ID:: 200118741

PubMed Full text in PMC Similar studies

Select item 2001187287.

Identification of Jun loss that promotes resistance to HDAC inhibitor Entinostat through Myc signaling in Luminal breast cancer (expression)

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11383
27 Samples

Download data: TXT

Series

Accession:: GSE118728

ID:: 200118728

PubMed Full text in PMC Similar studies

Select item 2001853058.

Transcriptome profiling of murine cardiomyocytes after treatment with recombinant murine Leukemia inhibitory factor (mLIF), murine Oncostatin M (mOSM) and human-like Oncostatin M orthologue (hlOSM).

(Submitter supplied) This study comparatively assesses downstream effects of exclusive activation of Leukemia inhibitory factor receptor (LIFR), Oncostatin M receptor (OSMR) and dual LIFR/OSMR signaling in murine, cultured cardiomyocytes upon administration of recombinant mLIF, mOSM and hlOSM that is capable to activate both receptors in murine cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE185305

ID:: 200185305

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000571309.

Combination of HDAC inhibitors and Azacytidine for Cancer Cell Selective Targeting of Esophageal Cancer Cells

(Submitter supplied) Esophageal cancers (ECs) are highly aggressive tumors with poor prognosis and few treatment options. This study investigated the possibility of treating esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) cells by inhibitors of broad and specific histone deacetylases (HDACi; SAHA, MS-275, FK228) and/or of DNMT (Azacytidine, AZA). Drug targets (HDAC1,2,3 and DNMT1) were present in non-neoplastic (HET-1A), ESCC (OE21) and EAC (OE33) cell lines. more...