Table 7.

Recommended Surveillance for Individuals with Chronic Granulomatous Disease

System/ConcernEvaluationFrequency in Healthy Person w/CGD & No Evidence of Infection or Chronic Inflammatory Symptoms
Early detection of minimally
symptomatic
infections &
noninfectious
complications
incl colitis,
pulmonary
granulomata,
& pulmonary
fibrosis
  • CRP & ESR; significant ↑s should prompt eval for infection.
  • CBC & albumin; presence of microcytic anemia & hypoalbuminemia may indicate development of colitis.
  • Liver chemistries; transaminase & alkaline phosphatase ↑ may indicate drug-related hepatotoxicity.
Every 3-4 mos
Early detection of inflammatory
&/or infectious
conditions
in females
heterozygous
for a CYBB
pathogenic
variant
  • Annual eval by a health care professional w/an eye toward concerns of invasive infection or for auto-inflammatory manifestations
  • To follow (as needed): referral to appropriate specialist & lab &/or radiologic eval per individual findings
Annually or if new concern arises

CRP = C-reactive protein; ESR = erythrocyte sedimentation rate

From: Chronic Granulomatous Disease

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