Table 4. [Other Conditions in the Differential Diagnosis of Chronic Granulomatous Disease]. - GeneReviews®

Disorder	Clinical Characteristics	Comment
Allergic bronchopulmonary aspergillosis (ABPA)	Pulmonary hypersensitivity reaction to Aspergillus fumigatus & other molds; most commonly seen in asthmatics & persons w/cystic fibrosis	Diagnosis of ABPA is based on history, ↑ serum concentration of IgE, blood eosinophilia, immediate skin reactivity to Aspergillus fumigatus antigens, presence of precipitating serum antibodies to Aspergillus fumigatus, & specific imaging results, none of which are characteristic of CGD. ¹
Crohn disease	May present w/weight loss, abdominal pain, diarrhea, & colitis	Significant colitis → bowel obstruction, fistulae, & strictures can occur in persons w/CGD & can be an important cause of growth restriction. ²

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