Table 2.

Infections in CGD: Common Pathogens and Sites of Involvement

PathogenPresentation
Bacterial infections Staphylococcus aureus Soft-tissue infection; lymphadenitis; liver
abscess; osteomyelitis; pneumonia; sepsis
Burkholderia species: 1
  • B cepacia 2
  • B gladioli
  • B pseudomallei
Pneumonia; sepsis
Serratia marcescens 3More common:
  • Osteomyelitis
  • Soft-tissue infection
Less common:
  • Pneumonia
  • Sepsis
Nocardia species: 4, 5
  • N asteroides
  • N nova
  • N otitidiscaviarum
  • N farcinica
Pneumonia; osteomyelitis; brain abscess
Granulibacter bethesdensis 6Necrotizing lymphadenitis; sepsis; meningitis
Chromobacterium violaceum 7Sepsis
Francisella philomiragia 8Sepsis
Fungal infections 9 Aspergillus species:
  • A fumigatus
  • A nidulans
  • A viridinutans
  • A flavus
  • A terreus
  • A niger
Pneumonia; osteomyelitis; brain abscess; lymphadenitis
Paecilomyces species:
  • P variotti
  • P lilacinus
Pneumonia; soft-tissue infection; osteomyelitis
Other molds:
  • Geosmitha argillacea 10
  • Cephalosporum species
  • Chaetomium strumarium
  • Phialophora richardsiae
  • Scedosporium apiospermum
  • Exophiala species
  • Cladosporium species
  • Zygomycete species
  • Acremonium species
  • Neosartorya udagawae
  • Phellinus species 11
Pneumonia; soft-tissue infection
Yeast
infections 		Candida
  • C albicans
  • C glabrata
  • C lusitaniae
Sepsis; soft-tissue infection; liver abscess
Trichosporon
  • T beigelii
  • T inkin
Arthrographis kalrae		Pneumonia; soft-tissue infection

From: Chronic Granulomatous Disease

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