Table 7.

Recommended Surveillance for Individuals with AIP-FIPA

System/ConcernEvaluationFrequency
Pituitary adenoma
  • Measure height & weight; calculate height velocity.
  • Evaluate for signs/symptoms & evaluate pubertal development.
Annually beginning at age 4 yrs until adulthood 1
Evaluate for signs/symptoms.Annually until age 30 yrs & every 5 yrs between ages 30 & 50 yrs, earlier if symptomatic
Serum IGF-1, prolactin, estradiol/testosterone, LH, FSH, TSH, free T4Annually from age 4 yrs to 30 yrs; to date, no secreting pituitary adenomas have developed after age 30 in those w/normal findings at age 30 yrs. Blood tests if symptomatic after age 30 yrs.
Pituitary MRI
  • Baseline at age 10 yrs unless indicated earlier due to clinical findings
  • Repeat MRI every 5 yrs until age 30 yrs (if clinical & pituitary function tests remain normal)
  • If clinical or biochemical abnormality between ages 30 & 50 yrs
1.

In children between ages four and ten years, it may be difficult to get annual blood samples. In these cases, monitoring symptoms and growth may be an acceptable alternative, as non-growth hormone-secreting adenomas before age ten years are rare.

From: AIP Familial Isolated Pituitary Adenomas

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